Autosomal Trisomies

Specific Knowledge Objectives
Students should understand:

• The clinical manifestations of common numeric and mosaic chromosomal anomalies;
• Errors of meiosis producing aneuploidy, association with maternal age, and determination of parental origin and stage of origin of nondisjunction;
• Recurrence risks for simple trisomies versus unbalanced translocations.

READING ASSIGNMENT: T & T, Chap. 9, pp 219-227.

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