About the School Robert Wood Johnson Medical School Department of Anesthesia -
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Both clinical and basic science research are done by the faculty of the Department of Anesthesia. The basic science effort is concentrated into the following three areas:

  • The use of various anesthetics and intravenous adjuvants to characterize the susceptibility of the blood brain barrier to disruption and effects on neurologic outcome in central nervous system ischemia.
  • An examination of the role of cyclic nucleotides in myocardial ischemia and hypertrophic cardiomyopathies.

Clinical research studies include the effect of various anesthetics or pharmacological agents on patient outcomes in anesthesia and surgery. These include investigations of the new ultra short-acting narcotic, remifentanil and its use in neurosurgery and extracorporeal shock wave lithotripsy; of the value of inhaled nitric oxide in patients with pulmonary hypertension in cardiac surgery; on the efficacy of various modalities in the treatment of chronic pain syndromes; on the enhancement of efficacy of epidural analgesia in parturients; of airway management policies and education on outcome in critically ill patients; on the management of anticoagulation and analgesia in patients undergoing cardiopulmonary bypass and the use of simulation training in critical care medicine education.

Manuscripts > Review Articles > Letters > Abstracts > Book Chapter

Manuscripts:

Chi OZ, Hunter C, Liu X, Weiss HR: Effects of 17ß-Estradiol on blood brain barrier disruption in focal ischemia during GABA A receptor inhibition. Horm Metab Res 37:209-213, 2005.

Kobayashi S, Bannister ML, Gangopadhay JP, Hamada T, Parness J, Ikemoto N: Dantrolene stabilizes domain interactions within the ryanodine receptor. J Biol Chem 280(8):6580-7,2005.

Liu X,Chi OZ, Weiss HR: Effects of metabotropic glutamate receptor stimulation on blood-brain barrier permeability during focal cerebral ischemia. Neurochem Res 29(10):1857-62, 2004.

Paul-Pletzer K, Yamamoto T, Ikemoto N, Jimenez LS, Morimoto H, Williams PG, Ma J, Parness J: Probing a putative dantrolene binding site on the cardiac ryanodine receptor. Biochem J 387(Pt 3): 905-9, 2005.

Sinha AK , Azevedo R, Chi OZ, Weiss HR: Down-regulation of AMPA glutamate receptors reduces cerebrocortical metabolic response to stimulation. Neurochem Res July 29(7):1425-1430, 2004.

Su J, Scholz PM, Tse J, Weiss HR: Effects of cyclic GMP and its protein kinase on the contraction of ventricular myocytes from hearts after cardiopulmonary arrest. Can J Physiol Pharmacol 82(11):986-92, 2004.

Su J, Zhang Q, Moalem J, Tse J, Scholz PM, Weiss HR: Functional effects of C-type natriuretic peptide and nitric oxide are attenuated in hypertrophic myocytes from pressure-overloaded mouse hearts. Am J Physiol Heart Circ Physiol 288(3):H1367-73, 2005.

Weiss HR, Katz E, Tse J, Scholz PM: Negative metabolic effects of cGMP are enhanced in obese rat hearts. J Cardiovasc Pharmacol 45(6):533-8, 2005.

Zhang Q, Lazar M, He Y, Tse J, Weiss, H, Scholz P: Cyclic GMP reduces myocardial stunning through non-cyclic GMP protein kinase mechanisms. J Cardiovasc Pharmacol 44(2), 235-43, 2004.

Zhang Q, Moalem J, Tse J, Scholz PM, Weiss HR: Effects of natriuretic peptides on ventricular myocyte contraction and role of cyclic GMP signaling. Eur J Pharmacol 14;510(3)209-15, 2005.

Zhang Q, Scholz PM, He Y, Tse J, Weiss HR: Cyclic GMP signaling and regulation of SERCA activity during cardiac myocyte contraction. Cell Calcium 37(3)259-66, 2005.

Review Articles:
Cohen S: Obstetric Anesthesia Update. The Female Patient Vol. 29,:16-21, 2004.
Letters:

Cohen S and Samet R: Catheter-related epidural abscesses-Reevaluating a true sterile technique, Acta Anaesthesiol Scand Jul; 48(6): 794-5, 2004.

Tse J , Cohen S, Stricker P: A simple and effective technique to increase oxygenation for patients with nasal cannulae during upper endoscopy. Anesthesiology 102(2): 484, 2005.

Abstracts:

Bermann M , Hammond J, Fischberg B: A new method for teaching a course on sedation and analgesia by non-anesthesiologists using innovative technologies. Poster presented (A-1360) at the American Society of Anesthesiologists Annual Meeting, October 26, 2004, New Orleans, LA.

Bermann M and Szkodny N: A new method for teaching a course on sedation and analgesia by non-anesthesiologists using innovative technologies. Poster presented at Clinical Informatics: Improving Health Care Quality through Information Technology Conference sponsored by UMDNJ/IAIMS Project, Piscataway, NJ, May 2005.

Chi O , Lee I, Liu X, Weiss H: 17ß-estradiol aggravates blood-brain barrier disruption in the focal cerebral ischemic area during GABA receptor inhibition. Poster presented (A-758) at the American Society of Anesthesiologists Annual Meeting, October 26, 2004, New Orleans, LA

Cohen S , Lin A, Pantuck C, Pantuck E, Boxer A: A comparison of combined spinal-epidural PCA analgesia with continuous epidural PCA analgesia alone for labor pain. Poster presented (A-1200) at the American Society of Anesthesiologists Annual Meeting, October 26, 2004, New Orleans, LA, Anesthesiology 101:A1200, 2004.

Cohen S , Lin A, Pantuck C, Pantuck E, Cioci L: Arrow versus B Braun epidural catheters for epidural block in obstetric patients. Poster presented (A-1199) at the American Society of Anesthesiologists Annual Meeting, New Orleans, LA October 26, 2004.

Cohen S , Fernandez N, Boxer A, Cioci L, Mangra C: Loss of consciousness from epidural sufentanil for labor analgesia. Poster presented at the New York State Society of Anesthesiologists PGA, New York, NY, December 11, 2004.

Cohen S , Lin A, Boxer A, Cioci L, Etan S, Wallis M, Amar D, Mangra C: Does stylet reinsertion upon reaching ligamentum flavum with an epidural needle reduce the incidence of accidental dural puncture? Poster presented at the New York State Society of Anesthesiologists PGA, December 11, 2004.

Cohen S, Lin A, Boxer A, Cioci L, Etan S, Wallis M, Amar D, Mangra C: Does stylet reinsertion upon reaching ligamentum flavum with an epidural needle reduce the incidence of accidental dural puncture? Research Poster Session, UMDNJ-RWJMS, New Brunswick, NJ, November 2004.

Cohen S , Shorstein A, Sakr A, Samet R, Stricker P: A comparison of epidural ropivacaine with lidocaine for cesarean section. SOAP 37 th Annual Meeting, Palm Desert, CA, May 2005.

Cohen S, Sakr A, Shorstein A, Samet R, Stricker P: Combined-spinal-epidural (CSE) anesthesia for cesarean section. SOAP 37 th Annual Meeting, Palm Desert, CA, May 2005.

Hall D , Lin A, Ginsberg S: From concept to codification: A survey of patient transport practices in New Jersey is used to change the NJ administrative code, which defines standards in licensed health care facilities. Poster presented (A-1318) at the American Society of Anesthesiologists Annual Meeting, New Orleans, LA, October 26, 2004.

Lin A, Hall D, Grzesiak R, Berman J, Grubb W: Tramadol dependence/abuse in pain management fellowship training program practices. Poster presented (S-315) at the International Anesthesia Research Society Annual Meeting, Honolulu, HI, March 14, 2005.

Hall D , Lin A, Ginsberg S: From Concept to Codification: A survey of patient transport practices in New Jersey is used to change the NJ Administrative Code, which defines standards in licensed health care facilities. Poster presented at Clinical Informatics: Improving Health Care Quality through Information Technology Conference sponsored by UMDNJ/IAIMS Project, Piscataway, NJ, May 2005.

Stricker P, Hall D, Kiss G, Grubb W : Lumbar epidural injection practices in the State of New Jersey. Poster presented (S-314) at the International Anesthesia Research Society Annual Meeting, Honolulu, HI, March 14, 2005.

Tse J , Su J, Zhang Q, Moalem J, Scholz P, Weiss H: Negative inotropic effects of C-type natriuretic peptide and nitric oxide are attenuated in pressure-overload-induced ventricular hypertrophy in mice. Poster presented (S-65) at the International Anesthesia Research Society Annual Meeting, Honolulu, HI, March 14, 2005.

Tse J , Weiss H, Katz M, Scholz P: Negative myocardial effects of cyclic GMP are enhanced in obese rats. Poster presented (S-32) at the International Anesthesia Research Society Annual Meeting, Honolulu, HI, March 14, 2005.

Tse J , Zhang Q, Scholz P, Weiss H: Aging blunts inotropic effects of triiodothyronine on isolated cardiac myocytes in rabbits. Poster presented (A-733) at the American Society of Anesthesiologists Annual Meeting, New Orleans, LA, October 26, 2004.

Tse J, Weiss HR, Kath E, Scholz PM: Negative myocardial effects of cyclic GMP are enhanced in obese rats. Can J Anaesth 52:A158, 2005.

Tse J, Zhang Q, Scholz PM, Weiss HR: Aging blunts effects of triiodothyronine on rabbit cardiac myocytes. Can J Anaesth 52:A159, 2005.

Woo C, Hall D, Grubb W : Thoracic paravertebral blockade with 5% xylocaine for chronic pain states. Poster presented (S-313) at the International Anesthesia Research Society Annual Meeting, Honolulu, HI, March 14, 2005.

Book Chapter:

Parness J : The Dantrolene Binding Site on RYR1 Implications for Clinical Therapy. In: Ryanodine Receptors: Structure, Function And Dysfunction In Clinical Disease, Wehrens XHT, Marks AR (ed), Springer Verlag, New York. Chapter 24, 244-251, November 9, 2004.

 
 

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