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Laboratory of Dr. Patrizia Casaccia
Department of Neuroscience and Cell Biology
UMDNJ-Robert Wood Johnson Medical School
675 Hoes Lane, Piscataway, NJ 08854
Tel. 732-235-4215 Fax. 732-235-4029
RESEARCH ARTICLES:
2007
He, Y., Dupree, J., Wang, J., Sandoval, J., Li, J., Liu, H., Shi, Y., Nave, K. A., and Casaccia-Bonnefil, P. (2007). The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron 55, 217-230.
Werner, H. B., Kuhlmann, K., Shen, S., Uecker, M., Schardt, A., Dimova, K., Orfaniotou, F., Dhaunchak, A., Brinkmann, B. G., Mobius, W., et al. (2007). Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci 27, 7717-7730.
Liu, A., Han, Y. R., Li, J., Sun, D., Ouyang, M., Plummer, M. R., and Casaccia-Bonnefil, P. (2007). The glial or neuronal fate choice of oligodendrocyte progenitors is modulated by their ability to acquire an epigenetic memory. J Neurosci 27, 7339-7343.the cover of this issue. Reviewed in Nature Neuroscience Review 8, 573
2006
Shen, S., Liu, A., Li, J. Casaccia-Bonnefil, P (2006) Epigenetic memory loss in the oligodendrocyte lineage cells in the aging brain. Neurobiology of Aging , in press.
Mastronardi, F. G., Wood, D. D., Mei, J., Raijmakers, R., Tseveleki, V., Dosch, H. M., Probert, L., Casaccia-Bonnefil, P., and Moscarello, M. A. (2006). Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation. J. Neurosci. 26, 11387-11396.
Liu, A. , Li, J. ,Marin-Husstege, M., Kageyama R., Fan, Y, Gelinas, C, Casaccia-Bonnefil., P. (2006). A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players EMBO J , 25(20):4833-42.
Marin-Husstege, M., He Y., Li, J., Kondo, T., Sablitzky, F. Casaccia-Bonnefil, P (2006). Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findings. Glia , 54:285-296.
Gil-Perotin S, Marin-Husstege M, Li J, Soriano-Navarro M, Zindy F, Roussel MF, Garcia-Verdugo JM, Casaccia-Bonnefil P. (2006). Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors. J Neurosci. ;26:1107-16.
Cunliffe, V., Casaccia-Bonnefil, P.. (2006) Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS. Mech. Devel. , 123:24-30.
2005
Gokhan, S., Marin-Husstege, M., Yu Yung , S, Fontanez, D., Casaccia-Bonnefil, P*. Mehler, MF (2005). Coordinate Regulation of Homeodomain and Basic Helix-Loop-Helix Transcription Factors Differentially Regulate Myelin Basic Protein Gene Expression. J. Neurosci. , 25:8311-21.
Shen, S., Li, J., Casaccia-Bonnefil, P.* (2005). Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. J. Cell Biol. 169: 577-589.
Bansal, R., Marin-Husstege,M., Winkler,S., Casaccia-Bonnefil P. (2005). FGF2-induced entry into S-phase is accompanied by increased levels of the cell cycle inhibitor p21Waf/Cip1: a paradoxical role for this molecule in the oligodendrocyte lineage. J. Neurosci. Res. , 80:360-8
Liu , A, Stadelman C., Mastronardi F., Moscarello M., Sobel A., Casaccia-Bonnefil, P., (2005). Inhibitors of morphological differentiation of oligodendrocyte progenitors are inappropriately re-expressed in the brain of patients with multiple sclerosis. J Neurosci. Jan 19;25(3):737-47
Marin-Husstege, M., Muggironi, M., Raban, D., Skoff. R Casaccia-Bonnefil P. (2004). Oligo- dendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones. Dev. Neurosci. , 26:245-54.
Crockett, D. Burnashey, M.,Muggironi, M.,Garcia, C., Casaccia-Bonnefil, P. (2005). The number of oligodendrocyte progenitors recruited to the lesioned spinal cord is modulated by the levels of the cell cycle regulatory protein p27Kip1. Glia , 49(2):301-8.
2004
Kim, D., Zhao, X., Tu, C., Casaccia-Bonnefil, P., Chao, MV (2004). The neurotrophins prevent apoptotic but not necrotic cell death following neuronal injury by signaling through their TRK receptor. J. Neurosurgery , 100(1):79-87.
2003
Liu A., M., Muggironi, M., Casaccia-Bonnefil, P. (2003). Oligodendrocyte process outgrowth in vitro is modulated by epigenetic regulation of cytoskeletal severing proteins. Glia ,44(3):264-74.
Petrone A., Dusa, A., Bianchi R., Casaccia-Bonnefil, P., Arancio, O., Sap.J. (2003). Receptor protein tyrosine phosphatase alpha is essential for hippocampal neuronal migration and long-term potentiation. EMBO J. , 22:4121-4131.
2002
Marin-Husstege, M., Muggironi, M., Liu A.X.., Casaccia-Bonnefil, P. (2002). Inhibition of histone deacetylase activity is necessary for oligodendrocyte lineage progression. J. Neurosci. 22(23): 10333-45.
Osterhout, D.J., Marin-Husstege, M., Abano, P. Casaccia-Bonnefil., P. (2002) Molecular mechanisms of enhanced susceptibility to apoptosis in differentiating oligodendrocytes. J. Neurosci. Res. 69(1): 24-29.
Doetsch, F. Verdugo, J.G., Caille I, Chao MV, Alvarez-Buyilla, Casaccia-Bonnefil, P., (2002) Lack of the cell cycle inhibitor p27Kip1 results in selective increase of transit amplifying cells for adult neurogenesis. J. Neurosci, 22:2256-2264.
Miskimins, R., Srinivasan, R., Marin-Hincapie M., Miskimins K., Casaccia-Bonnefil, P. (2002). P27Kip1 enhances myelin basic protein gene promoter activity. J. Neurosci. Res., 67:100-105.
1999-2001
Zeuzula, J., Casaccia-Bonnefil,P., Osterhout, D.J., Levine, J., Chao, M.V. Koff, A. (2001). P21Cip1 is required for the differentiationn of oligodendrocytes independently of cell cycle withdrawal. EMBO reports 2: 27-34.
Gentry J.,Casaccia-Bonnefil, P., Carter, B.D. (2000). Nerve Growth Factor activation of Nuclear Factor Kb through its p75 is an anti-apoptotic signal in RN22 Schwannoma cells. J. Biol. Chem. 275: 7558-7565.
Dowling, P., Raval, S., Husar,W., Casaccia-Bonnefil, P., Chao, M.V., Cook, S., Blumberg, B. (1999). Expression of the p75 neurotrophin receptor on oligodendrocytes in multiple sclerosis plaques. Neurology, 53(8):1676-82.
Casaccia-Bonnefil, P., Hardy, R.J., Teng, K.K., Levine, J.M., Koff, A., Chao, M.V. (1999). Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development, 126(18):4027-37.
Gu, C.G., Casaccia-Bonnefil, P., Srinivasan A., Chao, M.V. (1999). Oligodendrocyte apoptosis mediated by caspase activation. J. Neuroscience, 19(8):3043-3049.
1996-1998
Bongarzone, E.R., Foster, L., Byravan, S., Casaccia-Bonnefil, P., Schonmamm V., Campagnoni A.T. (1998). Two neuronal cell lines expressing the Golli-MBP gene display differences in their in vitro survival and in their interaction with glia. J. Neuroscience Res. 54:309-319.
Tikoo, R., Osterhout,DJ, Casaccia-Bonnefil, P., Preth, S., Koff, A., Chao, MVC (1998). Ectopic expression of p27 in oligodendrocyte progenitors induces growth arrest. J. Neurobiol., 36:431-440.
Yoon, S.O., Casaccia-Bonnefil, P.,Carter, B., Chao, M.V.C. (1998). Competitive signaling between TrkA and p75NGF receptors determines cell survival. J. Neuroscience, 18 (9):3273-3281.
Casaccia-Bonnefil, P., Kiyokawa, H., Tikoo, R., Friedrich, V., Koff, A., Chao, M.V.C. (1997). Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1. Genes & Dev.,11:2335-2346. the cover of this issue.
Tikoo, R.,Casaccia-Bonnefil, P., Chao, M.V., Koff, A. (1997). Changes in CDK2 and p27 Kip accompany glial cell differentiation of CG-4 cells. J. Biol. Chem., 272:442-447.
Casaccia-Bonnefil, P., Carter, B., Dobrowsky, R.T., Chao, M.V. (1996). Nerve growth factor mediated cell death of mature oligodendrocytes through the p75 neurotrophin receptor. Nature, 383:716-719.
Casaccia-Bonnefil,P., Aibel, L., Chao, M.V. (1996). Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death. J. Neurosci Res., 43:382-389.
REVIEWS:
Casaccia-Bonnefil, P. and Liu A.X. (2002) The relationshp between cell cycle molecules and oligodendrocyte differentiation. J. Neurosci. Res.
Casaccia-Bonnefil, P. (2000). Cell death in the oligodendrocyte lineage: a molecular perspective of life/death decisions in development and disease. Glia, 29:124-135.
Casaccia-Bonnefil P, Gu C, Khursigara G, Chao MV.(1999). p75 neurotrophin receptor as a modulator of survival and death decisions. Microsc Res Tech 45:217-24
Casaccia-Bonnefil P, Gu C, Chao MV. (1999). Neurotrophins in cell survival/death decisions. Adv Exp Med Biol 468:275-82.
Casaccia-Bonnefil, P., Kong, H.Y., Chao, M.V (1998). Neurotrophins: the biological paradox of trophic factors eliciting apoptosis. Cell Death and Diff 5:357-364.
Chao, M.V, Casaccia-Bonnefil, P., Carter, B., Chittka,S., Kong, H.Y., Yoon, S.O. (1998). Neurotrophin receptors: mediators of life and death. Brain Res. Rev. 26:295-301.
INVITED BOOK CHAPTERS:
Casaccia-Bonnefil, P., Gu, C.G., Khursigara, G., Chao, M.V. (1999). The p75 neurotrophin receptor as modulator of survival and death decisions. In Structural and Functional Studies on Nerve Growth Factor. Johnson, J., Silos-Santiago, I., Varela-Nieto, I. (eds.). New York, John Wiley Press.
Casaccia-Bonnefil, P., Gu, C.G., Chao, M.V.C. (1999). Survival/death decisions in the oligodendrocyte lineage. In The function of Glial Cells in Health and Disease: Dialogue between Glia and Neurons. R. Matsas, M. Tsacopoulos (eds.). New York, Plenum Press.
Kong, H., Casaccia-Bonnefil, P., Chao, M.V.C. (1998).Trophic nerve growth factors. In Handbook of Developmental Neurotoxicology. W. Slikker, Jr., Chang, L.W.(eds) Academic Press.