Biosafety
Animals in
Research (top)
Risks to Assess when
Selecting Clean Benches and Biosafety Cabinets for Animal Research, Baker Company
Acumen Newsletter, June 2000
Animal Facility
Biosafety Self-Audit Checklist, Princeton University
Rodent
Screening: Pathogen Screening of Biological Materials, Emory University Division
of Animal Resources, Discusses why tumors, tissues, immortal cell lines, embryonic
stem cells, serum andmammalian components of cell culture media used to culture cells that
will be inoculated into rodents should be screened for pathogens.
Guidelines
for Biomedical Facilities Using Sheep as Research Animals, Health Canada, Office of
Laboratory Security, December 2003
Elizabeth R. Griffin Research Foundation
Autoclave Safety (top)
Autoclave
Procedures, Michigan State University ORCBS
Autoclaves, University
of Washington, Environmental Health and Safety, January 2006
UCSF Autoclave Quality Control
Program, UCSF Environmental Health and Safety Biological Safety Updates, 1996
Biological Safety Cabinets (top)
Primary
Containment for Biohazards: Selection, Installation, and Use of Biological Safety
Cabinets, 3nd edition, 2007
Terminology Changes in the 2002 Revision of NSF 49 NSF/ANSI Standard # 49 – 2002 Class II Biological Safety Cabinets Types
Intro to Biological Safety Cabinets, The
Baker Company
Technical
Bulletin: Discussion of Canopy Versus Hard Connection Of Class II, Type A2 (formerly
Type A/B3) Biological Safety Cabinets, Nuaire, December 2003
Biological Sampling (top)
EPA
Microbiology Page, This site provides EPA resources relating to sampling
for microorganism
Aerotech
Laboratories Inc. This commercial site has detailed sampling information for
biologicals.
Biosafety Levels
and Checklists (top)
Evaluating
Biosafety Level Three Laboratories: An In-Depth Look at the Facility, Its Operations, and
Documentation, a presentation given at the 2002 AIHCE: Forum 239 EH&S: Lessons
Learned at Colleges and Universities by Stephen Kowalewsky
The
1,2,3's of Biosafety Levels, Johathon Richmond, Ph.D., CDC Office of Health and
Safety, Slideset and text of presentation presented at 5th National Symposium on
Biosafety: Rational Basis for Biocontainment
CDC Slideset: Biosafety in the
Laboratory. Slides are in pdf format
UMDNJ-EOHSS Factsheet:
Biosafety Level 2 Checklist
Biosafety Levels and Risk Groups for Specific Microorganisms (top)
Agent Summary Statements for Bacterial, Fungal, Parasitic, Rickettsial, Viral, Arboviruses and Related Zoonotic Viruses, Toxins and Prion Disease Agents, is in Section VIII of the CDC/NIH Biosafety in Microbiological and
Biomedical Laboratories (BMBL) 5th Edition,
American Biological Safety Association
Risk Group Classification for Infectious Agents (Bacteria, Virus, Fungi, Parasites)
Material Safety Data Sheets
for Infectious Microorganisms from Canada's Health Protection Branch - Laboratory
Centre for Disease Control.
Bloodborne
Pathogens (top)
Bloodborne Pathogens in Healthcare Settings, US CDC
The June 29, 2001 edition of the MMWR, Recommendations
and Reports, Updated U.S.
Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV,
and HIV and Recommendations
for Postexposure Prophylaxis
APPENDIX A. Practice Recommendations for
Health-Care Facilities Implementing the U.S.
Public Health Service Guidelines for
Management of Occupational Exposures to Bloodborne Pathogens
APPENDIX B. Management of
Occupational Blood Exposures
APPENDIX C. Basic and
Expanded HIV Postexposure Prophylaxis Regimens
The Hepatitis Branch of the
Center for Disease Control has a site which details the epidemiology and prevention of
Hepatitis A to E in a slide-show
format.
OSHA Information on Bloodborne Pathogens
29 CFR 1910.1030 - Occupational Exposure to Bloodborne Pathogens
Needlestick Safety and Prevention Act
Canada Office of
Laboratory Security (top)
Health Canada, Office of Laboratoary
Security Canada's national centre of expertise for biosafety and biocontainment,
namely the Office of Biosafety (OBS), was amalgamated into the new Office of Laboratory
Security from the Laboratory Centre for Disease Control (LCDC) in June 2000
Health Canada, Laboratory Biosafety
Guidelines, 3rd edition, 2004
Quarterly Biosafety Listings,
Health Canada, A bibliography of recently published literature relating to biosafety
issues, published every three months.
CDC-NIH Guidelines (top)
The CDC-NIH publication, "Biosafety in Microbiological
and Biomedical Laboratories, 5th edition" lists the appropriate biosafety levels
for numerous microorganisms, and the work practices which should be implemented. (NOTE:
For a much more extensive listing of organisms and risk groups, see the NIH document
listed under Recombinant DNA).
Errata for Biosafety in
Microbiological and Biomedical Laboratories (BMBL) - 4th edition (Adobe Acrobat Format)
Cell Culture (top)
Howard Hughes Medical Institute has an online
laboratory safety course entitled, Knowing
How To Practice Safe Science, which includes a section on Mammalian Cell
Culture.
Cell Sorters
(Biosafety Issues) (top)
Biosafety
Guidelines for Sorting of Unfixed Cells , The International Society of Analytical
Cytology Biohazard Working Group, Cytometry 28:99-117 (1997) PDF file
Editorial
Introduction to Biosafety Guidelines for Sorting of Unfixed Cells, (PDF File)
Biosafety
Concerns for Flow Cytometric HIV Immunophenotyping, Mednet at UCLA
Scripps Biohazard Review Form for Sorting
Applications
Containment Facilities(top)
Biosafety
Level 3, Physical Containment, Lawrence Berkeley National Laboratories
Laboratory Security and Emergency Response Guidance for Laboratories Working With Select Agents, CDC, December 6, 2002 / 51(RR19);1-8
Disinfection (top)
Antimicrobial
Chemical/Registration Indexes This US Environmental Protection Agency site has
listings of EPA's registered antimicrobial products effective against certain blood
borne/body fluid pathogens, Mycobacteria spp (tubercle bacteria), human HIV-1 virus,
Hepatitis B or Hepatitis C virus as well as products classified as sterilizers and
products used for medical wastes. The lists are organized alphabetically by product names
and by numerical order of their EPA Reg#. Information is current as of December 2, 2002.
CDC References: Inactivation of HIV
Liquid Disinfection
Comparison Guide, from the University of Virginia Office of Environmental Health and
Safety
WA Rutala & DJ Weber, New Disinfection and Sterilization
Methods, Emerging Infectious Diseases, Volume 7, No. 2., CDC, March-April
2001
Equipment -
Containment (top)
The equipment listed in this section is
provided for information purposes and is not endorsed by the AIHA Laboratory Health and
Safety Committee.
Omni aerosol-sealed homogenizers
Freezing/Thawing Specimens
(top)
Laboratory
Incidents Involving Cryongens, AIHA Laboratory Health and Safety Committee
Cryogenic Materials,
East Carolina University Office of Environmental Health and Safety
Fungi (top)
Biosafety
Considerations in Handling Medically Important Fungi, Med
Mycol. 1998;36 Suppl 1:258-65.
Hazards
to Lab Staff Posted By Fungal Pathogens, J Hosp Infect. 1995 Jun;30 Suppl:358-63
Importation
Permits for Etiologic Agents, Cell Lines and Live Animals (top)
The Department of Health and Human Services
(DHHS)/Centers for Disease Control and Prevention (CDC)Application to Import Etiologic
Agents
United States Department of Agriculture (USDA)/ Animal
and Plant Health Inspection Service (APHIS)
Application to Import Organisms, Vectors, Cell Cultures or Live Animals
International
Agencies (top)
EBSA,
European BioSafety Association
International
Veterinary Biosafety Workgroup
Public Health
Department, United Kingdom
Institut
de Veille Sanitaire, France
Santé Publique : sites francophones
Public
Health Agency of Canada,
Health Canada, Office of
Laboratory Security, Canada's national centre of expertise for biosafety and
biocontainment, namely the Office of Biosafety (OBS), was amalgamated into the new Office
of Laboratory Security from the Laboratory Centre for Disease Control (LCDC) in June 2000
Journals/Bulletins/Surveillance (top)
Journal of the American
Biological Safety Association
British Medical Journal
Journal of the American Medical Association
Emerging
Infectious Diseases
CDC Wonder
The Program for Monitoring
Emerging Diseases (Promed)
The Research Roundtable
- a Newsletter for Clinical Research Investigators, Institutional Review Boards, CROs,
SMOs and the Pharmaceutical Industry
EBSA
Newsletters
Disease Outbreak News,
World Health Organization
Listserv - Biosafety (top)
Biosafty, A Biosafety Discussion Group, is an excellent
resource for exchanging biosafety information with colleagues all over the world. For information about subscribing, go to the following url address: http://www.absa.org/resgroups.html
Material Safety
Data Sheets for Infectious Substances (top)
Material Safety Data Sheets
for Infectious Substances from Canada's Health Protection Branch - Laboratory Centre
for Disease Control. The MSDSs are organized to contain health hazard information such as
infectious dose, viability (including decontamination), medical information, laboratory
hazard, recommended precautions, handling information and spill procedures.
Meningococcal
Disease (top)
Laboratory-acquired
Meningococcal Disease - United States, 2000 Morbidity and Mortality Weakly
Reports (MMWR) February 22, 2002 / 51(07);141-144
Organizations (top)
American Biological
Safety Association
European Biological
Safety Association
Canadian Infectious Disease Society
World Health Organization
Prions (top)
Second
possible case of transfusion-transmitted variant CJD, CDR
Weekly Volume 14 Number 34, Health Protection Agency, August 19, 2004
Statement of the Swiss
Expert Committee for Biosafety on BSE Diagnostics: Classification and Safety
Measures, June 2001
Prions-
Inactivation, A study by Brown et al., in PNAS 97(7): 3418-21 March 2000 on the
heat resistance of hamster-adapted scrapie agent.
Guidelines for Biomedical Facilities Using Sheep as Research Animals, Health
Canada, Office of Laboratory Security, December 2003
Transmissible
Spongiform Encephalopathy Agents: Safe Working and the Prevention of Infection (Guidance
prepared in consultation with HSE, by the Advisory Committee on Dangerous Pathogens and by
the Spongiform Encephalopathy Advisory Committee, May 1998
WHO Factsheet on Bovine
spongiform encephalopathy (BSE), November 2002
WHO fact sheet on Variant
Creutzfeldt-Jakob disease, November 2002
Program Content
Examples (top)
Yale Biosafety Manual,
Yale University Office of Environmental Health and Safety, July 2001
Laboratory
Biosafety Self-Audit Checklist, Princeton University
Johns Hopkins Biosafety
Q Fever (top)
Q Fever
Summary for Research Personnel, UCSF
Q Fever, Health Canada
Occupational Safety and Health Answers, 1999
Q Fever Control Policy, University
of Florida, October, 2005
Recombinant DNA
Guidelines (top)
NIH Guidelines for
Research Involving Recombinant DNA Molecules, (April 2002). Appendix B of this
document has an extensive listing of organisms and biosafety levels. Appendix M
pertains to Gene Transfer Protocols.
Notice
Regarding Human Gene Transfer, November 19, 2001 Federal Register, Volume 66, Number
223, The actions described in this Notice amend the NIH Guidelines to enhance oversight of
human gene transfer research by modifying the requirements for the reporting and analysis
of serious adverse events in human gene transfer research studies governed by the NIH
Guidelines.
Institutional
Biosafety Committees - Information and Resources, NIH Office of Biotechnology
Activities
Regulated Medical
Waste (top)
CDC Laboratory Waste Disposal Guide Slideset
Managing and
Disposing of Medical Waste Fact Sheet, The Office of Environmental Health and Safety,
University of California Berkeley, May 2002
Management of Regulated Medical
Waste at Cornell University (pdf file) 11/2000
Rutgers University Policy for the Disposal of Biological Waste
Sampling
Methods (top)
Bioaerosols Sampling, Indoor Air,
NIOSH Manual of Analytical Methods, 4th Edition (pdf file)
Aerobic Bacteria by GC-FAME, NIOSH
Manual of Analytical Methods, 4th Edition (pdf file)
Mycobacterium Tuberculosis - Airborne,
NIOSH Manual of Analytical Methods, 4th Edition (pdf file)
Recommended Sampling for Microbial Aerosols,
from Air Sampling Instruments for Evaluation of Atmospheric Contaminants,
5th edition
Mold Contamination Sampling,
EMSL
Indoor Molds: Methods
for Monitoring Mold in the Environment,
Select Agents (top)
Destruction of Select Agents,
University of Pennsylvania, EHRS,
CDC Select Agent
Program and materials
USDA Biological Agents and Toxins materials
ABSA
Comments on Select Agent Rule
Howard Hughes Medical Institute Comments on Select Agent Rule
Shipping of
Specimens/IATA (top)
FedEx Dangerous
Goods Shipping Service Information and forms
Packaging Infectious
Substances With or Without Dry Ice, University of Nebraska- Lincoln, Environmental
Health and Safety, July 2005
Shipping Diagnostic Specimens,
University of Nebraska- Lincoln, Environmental Health and Safety, August 2005
Shipping Items With Dry Ice
That Are Not Dangerous Goods, University of Nebraska- Lincoln, Environmental Health
and Safety, September 2005
Univeristy of New Hampshire, Office of
Environmental Health and Safety publications:
UNH Shipment
of Biological Materials Manual, February 2006
UNH Guide to
Shipping With Dry Ice, October 2005
The U.S. DOT Small
Quantity Exceptions 49 CFR §173.4 -
A supplement to the UNH Shipment of Hazardous Materials Manual, September 2003
Shippers Declaration
for Dangerous Goods, created by Andy Globe at UNH-OEHS
Printable Class 9 Label
for dry ice
SARS Packaging
Diagnostic Specimens for Transport: Summary Instructions, CDC, April 23, 2003
Nitrogen "Dry
Shippers," University of Washington, Environmental Health and
Safety, TIPS, May 2002
Packaging, Labeling and
Shipping Infectious Substances, CDC Division of Laboratory Systems, National
Laboratory Training Network
Shipment of Biological and
Infectious Material, Cornell Biological Safety
Shipping
of Biological Materials, Recombinant DNA and Dry Ice, UMDNJ-EOHSS, January 2005
Saf-T-Pak
Inmark,
Inc
Exakt-Pak
IATA
Dangerous Goods and Safety Worldwide
World Health Organization (WHO), Transport
of Infectious Substances Background to the
amendments adopted in the 13th revision of the United Nations Model Regulations guiding
the transport of infectious substances, 2004
Interstate Shipping of Etiologic Agents
Transportation
of Hazardous Materials: Infectious, Patient Specimens, Biological and rDNA,
University of Wisconsin, Office of Biological Safety, January 2005
FAA Regulations in
Clinical Research, The Research Roundtable (If the link does not work,
copy and paste the following into your browser: http://www.researchroundtable.com/FAA%20Regulations.htm
Synthetic Biology (top)
Extreme Genetic Engineering: An Introduction to Synthetic Biology, ETC Group
Safety and Ethical Aspects of Synthetic Biology, Synbiosafe
Videotape proceedings of The Second International Conference on Synthetic Biology. University of California, Berkeley webcast. The May 22, 2006 presentations are on safety and security.
Training Content
Examples (top)
UMDNJ Bloodborne Pathogens/Biosafety Training
Biosafety/Bloodborne
Pathogens/Universal Precautions Training , University Nebraska - Lincoln Environmental
Health and Safety, Scroll down and click on the appropriate link to access this program
which has enjoyable graphics and sound. You will need to have Macromedia
flash player installed on your computer to access the training.
Live Virus
Worker Web Training, Princeton Univesity, November 2003
Bloodborne Pathogens,
University of Wisconsin-Milwaukee, Department of
Environmental Health, Safety & Risk Management
Oklahoma State University Bloodborne Pathogens Online Training Module and
Quiz
University
of Wisconsin Bloodborne Pathogens Reference and Training Manual
LLNL Working Safely With Blood and Blood-Borne Pathogens Refresher
Howard Hughes Medical Institute has an online
laboratory safety course entitled, Practicing
Safe Science, which includes sections on Mammalian Cell Culture Hazards, and
Working with Human Blood.
Hazardous Materials
Shipping and Transportation Awareness Training, University of
Wisconsin - Milwaukee, Office of Biological Safety, May 2006
Tuberculosis (top)
Mycobacterium Tuberculosis:
Assessing your Laboratory, The Association of State and Territorial Public Health
Laboratory Directors and Public Health Practice Program Office, CDC, 1995
Vaccination (top)
June 22, 2001 MMWR, Vaccinia (Smallpox) Vaccine
Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2001
December 26, 1997 MMWR, Immunization of Health-Care
Workers, Recommendations of the Advisory Committee on Immunization Practices (ACIP)
and the Hospital Infection Control Practices Advisory Committee (HICPAC)
Vacuum System
Protection (top)
Protection
of Biosafety Cabinet (Tissue Culture Hood) Vacuum Lines, UCSF Environmental
Health and Safety Biological Safety Update, January 1999
Virus-Specific
Information (top)
Hantavirus (top)
Laboratory Management of Agents
Associated with Hantavirus Pulmonary Syndrome: Interim Biosafety Guidelines, MMWR May13, 1994/Vol.43/No.RR-7
Influenza (top)
Interim CDC-NIH Recommendation for Raising the
Biosafety Level for Laboratory Work Involving Noncontemporary Human Influenza Viruses,
Excerpted from the draft Biosafety in Microbiological and Biomedical Laboratories, 5th
edition.
Influenza - Swine Flu - H1N1 (top)
H1N1 Flu: Interim Guidance for Clinicians and Public Health Professionals
Poliovirus (top)
Materials
posted by the American Biological Safety Association regarding the Nationwide Survey for
Wild Polioviruses
Press-Ready Announcement of Nationwide Wild
Poliovirus Survey October 2002: Who, When, What, Why
Notice: Nationwide Survey of Biomedical
Laboratories for Containment of Wild Poliovirus, October 1, 2002
Poliovirus Laboratory Containment
Preparedness Part 1
Poliovirus Laboratory Containment Preparedness
Part 2
Preventing
Polio from Becoming a Reemerging Disease, Panel Summary from the 2000 Emerging
Infectious Diseases Conference in Atlanta, Georgia, Emerging Infectious Diseases, Vol.
8, No. 10, October 2002
Global Polio
Eradication Initiative - provides information about poliovirus, the disease and
eradication strategies and progress
Global Polio Eradication
Program
Photo exhibition by Sebastião
Salgado, documenting the final stages of the polio eradication campaign in the
remaining endemic countries.
SARS (top)
CDC Interim Laboratory Biosafety
Guidelines for Handling and Processing Specimens Associated with Severe Acute Respiratory
Syndrome, August 18, 2003
CDC
SARS Website
WHO
SARS Information
Summary of the
Discussion and Recommendations of the SARS Laboratory Workshop 22 October 2003, World
Health Organization
SARS Packaging
Diagnostic Specimens for Transport: Summary Instructions, CDC, April 23, 2003
West-Nile Virus (top)
Epidemic/Epizootic
West Nile Virus in the United States, Revised Guidelines for Surveillance, Prevention and
Control, Center for Disease Control and Prevention, April 2001
Laboratory-Acquired West Nile
Infections, United States, 2002, MMWR Weekly, December 20, 2002, 51(50);1133-1135
Biosfety Advisory, West Nile Virus,
Health Canada, Office of Laboratory Security, June 2003
West Nile information, Health
Canada
World Health
Organization (top)
Laboratory
Biosafety Manual, WHO, 2nd edition, 2003
Revision Date: 11/30/2008
url: http://www2.umdnj.edu/eohssweb/aiha/technical/biosafety.htm
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