Department of Molecular Genetics, Microbiology and Immunology

Current Concepts of Immunology (MICR-6605)

Rutgers course number: 16:681:543

(3 credit course) Spring 2007 Semester.
Course Director: Yufang Shi

Please note that this course is only offered every two years. It will be held on Mondays and Wednesdays from 1:10pm-2:30pm in Room V-10 of the RWJMS Research Tower.

The immune response is an evolutionarily conserved defense mechanism involving a complex network of interacting molecules and cells that specifically recognize and respond to agents foreign to our body.

This course provides current concepts of immunology. It will emphasize the organization and evolution of the immune system, genetic basis of generation of diversity, MHC gene structure and function, development and selection of lymphocytes, lymphocyte activation, and the regulation of immune tolerance. The effector mechanisms of immune reactions cover antigen-antibody reactions, cytokines, and the cell mediated immune responses. Basic principles of immunity to microbes and cancer cells are introduced.

Prerequisite: permission of the coordinator; contact Dr. Yufang Shi (732-235-4501, shiyu@umdnj.edu).

Text Book: Immunobiology: The immune system in health and disease, 6th Edition. 2004, by Charles Janeway, Paul Travers, M Walport, and M Shlomchik (For reference only, not required).

Schedule

Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Introduction and History of Immunology	January 21
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Cells and Tissue of the Immune System	January 26
Arnold Rubin Robert Wood Johnson Medical School rubinar@umdnj.edu	Hematopoiesis	January 28
Debra Laskin Rutgers University laskin@eohsi.rutgers.edu	Innate Immunity / Toll-Like receptors	February 2
Beverly Barton New Jersey Medical School bartonbe@umdnj.edu	Antibody structure and antibody diversity – B-cell and T-cell receptor	February 4
Alexander Izaguirre Robert Wood Johnson Medical School izaguial@umdnj.edu	MHC Molecules	February 9
Alexander Izaguirre Robert Wood Johnson Medical School izaguial@umdnj.edu	Antigen presentation/Dendritic Cells	February 11
Guy Werlin Rutgers University werlen@biology.rutgers.edu	T-cell Development	February 16
Arnold Rabson Cancer Institute of New Jersey rabson@cabm.rutgers.edu	Lymphocyte Signal Transduction	February 18
Lorie Covey Rutgers University covey@biology.rutgers.edu	B-cell Development	February 23
Wenchao Song University of Pennsylvania song@spirit.gcrc.upenn.edu	Complement	February 25
Sidney Pestka Robert Wood Jophnson Medical School Pestka@umdnj.edu	Interferons and Immune Response	March 2
Beverly Barton New Jersey Medical School bartonbe@umdnj.edu	Cytokine and Immune Responses	March 4
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Type 1 and Type 2 helper cells	March 9
Guy Werlin Rutgers University werlen@biology.rutgers.edu	NK, NKT and Innate-Like T cells	March 11
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Mid-Term Exam	March 23
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Immune Regulation and Tolerance	March 25
Edmund LattimeCancer Institute of New Jersey Edmund.Lattime@UMDNJ.EDU	Tumor Immunology	March 30
Edmund Lattime Cancer Institute of New Jersey Edmund.Lattime@UMDNJ.EDU	Vaccine Development	April 1
Lorie Covey Rutgers University covey@biology.rutgers.edu	Immunity in Infectious Diseases	April 6
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Phylogeny of the Immune System	April 8
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Mechanisms of Apoptosis and Cytotoxicity	April 13
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Immunosuppression and Transplantation	April 15
Alexander Kusnecov Rutgers Universality kusnecov@rci.rutgers.edu	Psychoneuroimmunology	April 20
Leonard Sigal Bristol-Myers Squibb leonard.sigal@bms.com	Autoimmunity	April 22
Leonard Sigal Bristol-Myers Squibb leonard.sigal@bms.com	Immunodeficiency	April 27
Roger Strair Cancer Institute of New Jersey strairrk@umdnj.edu	Transformation and Malignancy of the Immune System	April 29
Carol R. Gardner Rutgers University cgardner@eohsi.rutgers.edu	Inflammation and Hypersensitivity	May 4
Yufang Shi Robert Wood Johnson Medical School shiyu@umdnj.edu	Final Exam	May 6