The Graduate Program in Neuroscience

Faculty Profile
Arnold G. Hyndman
Professor Cell Biology & Neurobiology BA 1974, Princeton PhD 1978, UCLA Postdoctoral Training: 1979 - 1981, UCSD
Rutgers University Division of Life Sciences Nelson Biological Labs 604 Allison Road Piscataway, NJ 08854 (732) 445-4683 FAX: (732) 445-2175 E-mail: hyndman@rci.rutgers.edu Laboratory Home Page
Research Interests		Research Techniques
The in vitro examination of factors that may regulate the development and maturation of retinal neurons.		Cell culture Histochemistry Microscopy
Research Summary
Factors that regulate and control the development of the CNS are not fully understood, although it is likely they are a result of programmed gene expression, as well as, specific cell to cell interactions. It is known that a variety of biological agents can affect neuronal cell development. The focus of my laboratory is to examine various molecules that may have a role in neural development. I have chosen to use the retina of the chick embryo as a model system. Using techniques developed and refined in my laboratory, pure cultures of neurons or glial are also used in addressing questions without the complication of interactions between neurons and glia. Of particular interest is the in vitro examination of factors that may regulate the development and maturation of retinal neurons.

Key References
For complete list: PubMed Hyndman, A.G., (1991 ) High affinity binding of transferrin in cultures of embryonic neurons from the chick retina. Brain Res. 564:127-131. Hyndman, A.G., Hockberger, P.E., Zeevalk, G.D. & Connor, J.A., (1991) Transferrin can alter physiological properties of retinal neurons. Brain Res. 561:318-323. Hyndman, A.G., (1993) Identification of a population of amacrine cells rich in insulin receptors. Develop. Brain Res. 75:289-292. Zeevalk, G., Davis, N., Hyndman, A.G., & Nicklas, W., (1998) Origins of the extracelluar glutamate release during total metabolic blockade in the immature retina. J. Neurochem. 71:2373-2381. Cho, S., Lucas, J.L. &, Hyndman, A.G., (1999) Transferrin binding protein is expressed by oligodendrocytes in the avian retina. Brain Res. 816:229-233.