UMDNJ
Robert Wood Johnson Medical School
675 Hoes Lane
Piscataway, NJ 08854

Office; (732) 235-5768
Lab; (732) 235-4144
FAX: (732) 235-4825

wadswort@umdnj.edu

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Axon Guidance, Nervous System Development

• Genetics and Molecular
  Biology

In wiring the nervous system, axons extend sometimes over considerable distances to find their targets. We are studying molecules and the mechanisms that guide axon migrations. We use the nematode model organism C. elegans because of the powerful genetics and molecular techniques that are available to study the functions of molecules within a living organsim.

For complete list: PubMed

Wadsworth, W. G., Bhatt, H., and Hedgecock, E. M. (1996)
Neuroglia and pioneer neurons express UNC-6 to provide global and local netrin cues for guiding migrations in C. elegans.
Neuron 16, 35-46

Lim, Y.-S., Mallapur, S., Kao, G., Ren, X.-C., and Wadsworth, W. G. (1999)
Netrin UNC-6 and the regulation of branching and extension of motoneuron axons from the ventral nerve cord of C. elegans.
J Neurosci 19, 7048-7056

Kim, S., Ren, X.-C., Fox, E., and Wadsworth, W. G. (1999)
SDQR migrations in C. elegans are controlled by multiple guidance cues and changing responses to netrin UNC-6.
Development 126, 3881-3890

Ren, X. C., Kim, S., Fox, E., Hedgecock, E. M., and Wadsworth, W. G. (1999)
Role of netrin UNC-6 in patterning the longitudinal nerves of Caenorhabditis elegans.
J Neurobiol 39, 107-18

Kim, S., and Wadsworth, W. G. (2000)
Positioning of longitudinal nerves in C. elegans by nidogen.
Science 288: 150-154