UMDNJ - ROBERT WOOD JOHNSON MEDICAL SCHOOL
DEPARTMENT OF PATHOLOGY AND LABORATORY MEDICINE

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  Faculty Information

Karel Raška, Jr., M.D., Ph.D.

Position:  Professor,  Department of Pathology and Laboratory Medicine

Administrative

Department: Pathology and Laboratory Medicine

Lab Url:

Department of Laboratory Medicine & Pathology
St. Peter's University Hospital
254 Easton Avenue
New Brunswick, NJ 08901

Phone Number:
732-745-6677

Fax Number: 732- 828-3858

Email Address: jkraskamd@aol.com

Clinical and Research Interests
 
 
 

Training

 
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Charles University School of Medicine, Prague, Czechoslovakia, 1956-62

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Teaching Assistant, Institute of Physics, Charles University, Prague, 1957-58

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Research Assistant, Research Institute for Hematology and Blood Transfusion, Prague, Czechoslovakia, 1958-60

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Research Assistant, Department of Protein Biochemistry Institute of
Organic Chemistry and Biochemistry,1960-62

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Graduated "Summa cum Laude" and Valedictorian, M.D., 1962

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Graduate School of Chemistry, Institute of Organic Chemistry and
Biochemistry, Czechoslovak Academy of Sciences, Prague.
Thesis: "The Mechanism of Action of 5-Azacytidine"
Ph.D. in Biochemistry, 1965.

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Commonwealth Fund Research Fellow, Department of Pharmacology,
Yale University School of Medicine, New Haven, Connecticut, 1965-66

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Research Associate, Department of Microbiology, Rutgers Medical
School and Institute of Microbiology, Rutgers University, The
State University of New Jersey, New Brunswick, New Jersey,1966-67.
 

Honors and Awards


1962        Graduated "Summa cum Laude" and Valedictorian, M.D., 1962
 

 
Certifications Licensure

Educational Council for Foreign Medical Graduates, Philadelphia,
Pennsylvania. ECFMG #183-801-1

The Federation of State Medical Boards of the United States, Fort Worth, Texas. FLEX #46451

The American Board of Pathology, Tampa, Florida Anatomic and Clinical Pathology
Special Competence: Immunopathology
 

  New Jersey #: 29875
New York #:
129366
Maine - #7979

Other: New Jersey Bio-analytical Laboratory Director - License #508
 


 

Office Address   Mailing Address
Department of Laboratory Medicine & Pathology
St. Peter's University Hospital
254 Easton Avenue
New Brunswick, NJ 08901
same
 
Selected Publications

PAPERS AFTER 1989

78.        Raška, Jr., K., Kim, H.C., Raška, III, K., Martin, E., Rašková, J., and Saidi, P.  Human Immunodeficiency Virus Infection in Hemophiliacs:  Long Term Prognostic Significance of the HIV Serologic Pattern.  Clin. Exp. Immunol. 77: 1-6 (1989).

79.        Kim, H.C., Raška, Jr., K., Trooskin, S., Saidi, P.  Immune Thrombocytopenia in HIV-Infected Hemophiliacs and Their Response to Splenectomy.  Arch Intern. Med. 149: 1685-1688 (1989).

80.        Voelkerding, K., Sandhaus, L., Kim, H.C., Wilson, J., Chittenden, T., Levine, A.J., and Raška, Jr., K.  Plasma Cell Malignancy in AIDS:  Association With Epstein-Barr Virus.  Am. J. Clin. Path. 92: 222-228 (1989).

81.        Degiannis, D., Czarnecki, M., Homer, L., Raška, Jr., K., and Rašková, J.  Normal T Lymphocyte Function in Patients With End Stage Renal Disease Hemodialyzed with "High-Flux" Polysulfone Membranes.  Am. J. Nephrol. 10: 276-282 (1990).

82.        Li, Bo-Liang, Zhao, Xiao-Xia, Liu, Xin-Yuan, Kim-Ahn, Hyon Suk, Raška, Jr., K., Schwartz, B., and Pestka, S.  Interferon Alpha Structure and Natural Killer Cell Stimulatory Activity.  Cancer Res. 50: 5238-5332 (1990).

83.        Ebright, Y., Raška, Jr., K, Gaur, S., Frenkel, L., Tsao, J., and Stein, S.  Antisense DNA-Analogs:  Inhibition of Human Immunodeficiency Virus.  NJ Med. 87: 10111-10115 (1990).

84.        Raška, I., Reimer, G., Jarnik, M., Kostrouch, Z., and Raška, Jr., K.  Does the Synthesis of Ribosomal RNA Take Place Within Nucleolar Fibrillar Centers or Dense Fibrillar Components?  Biology of the Cell 65: 79-87 (1989).

85.        Urbanelli, D., Sawada, Y., Rašková, J., Jones, N.C., Shenk, T., and Raška, Jr., K.  C-terminal Domain of the Adenovirus E1A Oncogene Product is Required for Induction of Cytotoxic T Lymphocytes and Tumor-Specific Transplantation Immunity.  Virology 173: 607-614 (1989).

86.        Raška, I., Koberna, K., Jarnik, M., Petrasevicova, V., Bednar, J., Raška, Jr., K., and Bravo, R.  Ultrastructural Immunolocalization of Cyclin/PCNA in Synchronized 3T3 Cells.  Exp. Cell Research 184: 81-89 (1989).

87.        Sandhaus, L., Voelkerding, K., and Raška, Jr., K.  Combined Utility of Gene Rearrangement Analysis and Flow Cytometry in the Diagnosis of Lymphoproliferative Disease in the Bone Marrow.  Hematologic Path. 4(3) 135-148 (1990).

88.        Novembre, F., Raška, Jr., K., and Holowczak, J.A.  The Immune Response to Vaccinia Virus Infection in Mice:  Analysis of the Role of Antibody.  Archives of Virol. 107: 273-289 (1989).

89.        Degiannis, D., Seibold, J.R., Czarnecki, M., Rašková, J., and Raška, Jr., K.  Soluble Interleukin-2 Receptors in Patients With Systemic Sclerosis:  Clinical and Laboratory Correlations.  Arthritis and Rheum. 33: 375-380 (1990).

90.        Gould-Fogerite, S., Mazurkiewicz, J.E., Raška, Jr., K., Lehman, J.M., Voelkerding, K., and Mannino, R.J.  Chimerasome-Mediated Gene Transfer In Vitro and In Vivo.  Gene 84: 429-438 (1989).

91.        Degiannis, D., Seibold, J.R., Czarnecki, M., Rašková, J., and Raška, Jr., K.  Soluble and Cellular Markers of Immune Activation in Patients With Systemic Sclerosis.  Clin. Immunol. and Immunopath. 56: 259-270 (1990).

92.        Voelkerding, K., Sandhaus, L., Belov, L., Frenkel, L., Ettiger, L.E., and Raška, Jr., K.  Proliferazione Clonale di B-linfociti in una Neonata Con Infezione Congenita da HIV With Trombocitopenia Immunitaria.  Am. J. Clin. Path., Edizione Italiane, supplemento 2/1989 145-149 (1989).

93.        Wiedenfeld, S.A., O'Leary, A., Bandura, A., Brown, S., Levine, S., Raška, Jr., K..  Impact of Perceived Self-Efficacy in Coping With Stressors on Components of the Immune System.  J. of Personality and Social Psychology 59: 1082-1094 (1990).

94.        Degiannis, D., Czarnecki, M., Hornung, N., Rašková, J., and Raška, Jr., K. Mixed Lymphocyte Reaction-Induced Release of Soluble IL-2 Receptor is an IL-2 Regulated Phenomenon.  Transplantation 51: 518-523 (1991).

95.        Degiannis, D., Czarnecki, M., Stein, S., Rašková, J., and Raška, Jr., K. Cyclosporine Induced Enhancement of Interleukin-1 Receptor Expression by PHA Stimulated Lymphocytes.  Transplantation 50: 1074-1076 (1990).

96.        Mehta, K.U., Bolanowski, J.P., Combates, N., and Raška, Jr., K.  Detection of HPV Type 6/11 by In-Situ Technique in Recurrent Tracheal Papilloma.  New Jersey Medicine 88: 187-191 (1991).

97.        Donati, D., Degiannis, D., Homer, L., Raška, Jr., K.,  and Rašková, J.  Production and Kinetics of Interleukin 1 in Hemodialysis:  In Vivo and in Vitro Studies.  Amer. J. Nephrology 11: 451-458 (1991).

98.        Donati, D., Degiannis, D., Homer, L., Gastaldi, L., Rašková, J., Raška, Jr., K..  Immune Deficiency in Uremia:  IL-2 Production and Responsiveness, and IL-2 Receptor Expression and Release.  Nephron. 58: 268-275 (1991).

99.        Hornung, N., Rašková, J., Raška, Jr., K., Degiannis, D.  IL-2 Responsiveness of Lectin-Induced Lymphoblasts:  Soluble IL-2 Receptor Release and Differential In Vitro Effects of Immunosuppressants.  Int. J. Immunopharmacology, 14: 753-760 (1992).

100.    Kim, H.S., Degiannis, D., Rašková, J., Raška, Jr., K.  Cyclosporine A and Prednisolone Inhibit Lectin and Alloantigen Induced Release of Soluble CD8:  Correlation With Proliferative Responses and Expression of Activation Markers on CD8 Lymphocytes.  Clin. Immunol., Immunopathol. 60: 27-39 (1991).

101.    Donati, D., Degiannis, D., Combates, N., Rašková, J., Raška, Jr., K.  Effects of Hemodialysis on Activation of Lymphocytes:  Analysis by in Vitro Dialysis Model.  Journ. Amer. Soc. Nephrology 2: 1490-1497 (1992).

102.    Kenyon, D.J., Dougherty, J., and Raška, Jr., K.  Tumorigenicity of Adenovirus-Transformed Cells and Their Sensitivity to Tumor Necrosis Factor α and NK/LAK Cell Cytolysis.  Virology 180: 818-821 (1991).

103.    Javier, R., Raška, Jr., K.,  MacDonald, G., and Shenk, T.  Human Adenovirus Type 9-Induced Rat Mammary Tumors.  J. Virol. 65: 3192-3202 (1991).

104.    Donati, D., Degiannis, D., Combates, N., Rašková, J., and Raška, Jr., K.  Evidence of Mononuclear Cell Activation by Hemodialysis.  ASAIO Transactions 37: M386-M387 (1991).

105.    Donati, D., Degiannis, D., Homer, L., Raška, Jr., K.,  and Rašková, J.  ASAIO Transactions 37: M391-M392 (1991).

106.    Javier, R., Raška, Jr., K., and Shenk, T.  Requirement for the Adenovirus Type 9 E4 Region in Production of Mammary Tumors.  Science 257: 1267-1271 (1992).

107.    Donati, D., Degiannis, D., Rašková, J., Raška, Jr., K.  Effect of Uremic Serum on the Responses of peripheral Blood Mononuclear Cells and Purified T Lymphocytes.  Kidney International, 42:681-689 (1992).

108.    Mikhail, N., Raška, Jr., K.,  Rašková, J., and Degiannis, D.  Effect of Verapamil on the IL-2 Binding to its Active Receptor and on the Release of IL-2 Receptor by Activated PBMC.  Immunopharmacology, 25:29-36 (1993).

109.    Degiannis, D., Luke-Gustites, D., Mikhail, N., Raška, Jr., K., and Rašková, J.  Binding of Phycoerythrin-Conjugated Interleukin-6 to in Vitro-Activated Human Peripheral Blood Mononuclear Cells-Effect of Immunosuppressive Agents and of a Calcium Channel Blocker.  Transplantation, 54:308-312 (1992).

110.    Degiannis, D., Hornung, N., Luke-Gustites, D., Rašková, J., and Raška, Jr., K.,  In vitro Study of the Significance and the Conditions of IL-4 Receptor Expression by Activated Lymphocytes Using Immunosuppressants and a Ca2+ Channel Blocker, Int. J. Immunopharmacology.  15:829-832 (1993).

111.    Hornung, N., Luke-Gustites, D., Rašková, J., Raška, Jr., K.,.,  and Degiannis, D., Responsiveness of Pre-activated B Cells to IL-2 and IL-6:  Effect of Cyclosporine A (CsA) and Rapamycin,  Transplantation.  56:985-990 (1993)

112.    Raška, Jr., K.:  Functional Domains of Adenovirus E1A Oncogenes which Control Interactions with Effectors of Cellular Immunity in "Molecular Repertoire of Adenoviruses," Current Topics in Microbiology and Immunology 199/III: 131-148, Springer, New York (1995).

113.    Sawada, Y., Raskova, J., Fujinaga, K., and Raška, Jr., K.:  Identification of Functional Domains of Adenovirus Tumor-Specific Transplantation Antigens in Types 2 and 12 by Viruses Carrying Chimeric E1A Genes.  Int. J. Cancer, 57: 598-607, (1994).

114.    Chen, T-L., Luo, I., Mikhail, N., Rašková, J., and Raška, Jr., K.:  Comparison of Flow and Image Cytometry for DNA Content Analysis of Fresh and Formalin-Fixed Paraffin-Embedded Tissue in Breast Carcinoma.  Cytometry 22:181-189, (1995).

115.    Kim, H-S., Raskova, J., Degiannis, D., and Raška, Jr., K.   :  Effects of Cyclosporine and Rapamycin on Immunoglobulin Production by Preactivated Human B Cells.  Clin Exp Immunol, 96: 508-512, (1994).

116.    Raška, Jr., K. and Ponzio, N.:  Cells and Tissues of the Immune System, in Immunology and Inflammation (Siegel, L. and Ron, J., Eds.), pp. 15-36 McGraw Hill, New York (1994).

117.    Sleat, D.E., Chen,T-L., Raška, Jr., K. and Lobel, P.: Increased Levels of and Processing of Glycoproteins Containing Mannose-6-Phosphate in Human Breast Carcinomas. Cancer Research 55; 3424-3430, 1995.

118.    Raška, Jr., K., and Chen, T-L.: Utility of DNA ploidy and S-Phase in Solid Tumors; Image Analysis versus Flow Cytometry in Single-Cell Preparations and Paraffin Sections in "Diagnostic and Research Potential of Image Analysis". New York University Post-Graduate Medical School, New York (1995).

119.    Combates, N.J., Degiannis, D., Raskova, J., Raška,Jr., K.: Direct Inhibition of Human CD8+ Lymphocyte Activation by Cyclosporine A and Rapamune-Sirolimus. Clin Immunol Immunopathol 77:221-228 (1995).

120.    Wheeler, R.B., Sofka, C.M., Amorosa, J.K., Raška,Jr., K., and Nosher, J.L.: Eosinophilic Granuloma (Radiology-Pathology Conference) NJ Medicine 92:526-528, (1995).

121.    Donati, D., Degiannis, E., Mazzola, E., Gastaldi, L., Raskova, J., Raskova, J., Raška,Jr., K., and Camuss, G.: Interleukin-1 Receptors and Receptor Antagonist in Haemodialysis.  Nephrol Dial Transplant 12:111-118 (1997).
 

Biographical Listings


 

Updated Date
07/25/2007

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