Cellular and Molecular Pharmacology Graduate
Courses
The information presented here is adapted
from the Catalogue
of the Rutgers University Graduate School - New Brunswick and the Catalogue
of the Molecular BioSciences* Core Curriculum. Additional information
about Rutgers University and the Molecular BioSciences Program is available
at these two sites.
Phar-5605
Cellular and Molecular Pharmacology:
(F)
3 cr.
Principles of Drug Action and Targeting
Pilch. Prerequisite: Permission of graduate director and instructor.
This is a didactic course focusing on
the basic principles underpinning modern cellular and molecular pharmacology.
There will be two 1.5 h lectures per week, some problem sets and two examinations.
Lecture topics include: Molecular Basis of Pharmacologic Selectivity, Drug
Targets, Adaptive Responses to Drugs, Disposition of Drugs and Genetic
and Molecular Approaches to Drug Therapy.
Phar-5574
Neuropharmacology
(S)
2 cr.
Meiners, Sonsalla. Prerequisite: Permission of the instructor.
Seminar presentations consider the mechanisms
of synaptic transmission in the nervous system, the role of voltage-and
ligand-gated ion channels, and G-protein coupled receptors in information
transmission. Material includes the regulation of the synthesis, storage,
release, and destruction of neurotransmitters.
Phar-TBA
Advanced Pharmacology Laboratory
(F/S)
3 cr.
Prerequisite: Permission of instructor.
Phar-5523
Drug Metabolism
(S)
2 cr.
Conney, Kauffman. Prerequisite: Permission of instructor.
Readings, seminars, and discussions emphasize
selected papers from the primary literature pertaining to the metabolism
of foreign chemicals. Critical discussions of publications that describe
the properties and regulation of foreign compound-metabolizing enzymes
in microorganisms, plants, insects, lower mammals, and humans. Consideration
of the significance of these enzymes for the metabolism and action of foreign
chemicals and endogenous substrates in intact cells and organisms.
Phar-5580
Drug Target Interactions
(F)
2 cr.
Gartenberg. Prerequisite: Permission of the instructor.
The basic principles of secondary and
tertiary structures of the nucleic acids will be emphasized by readings,
seminars, and discussions of the primary literature. These fundamentals
will be utilized in exploring various aspects of the nucleic acid biology
such as protein-nucleic and interactions, RNA-catalyzed reactions, and
nucleic acid pharmacology.
Phar-5581
Genomics in Cancer Therapeutics
(S)
3cr.
Banerjee, Welsh. Prerequisite: Biochemistry 501 and 502 or equivalent.
This course is designed for graduate students
of the life sciences. First year graduate students are particularly encouraged
to take this course. The format of this course is a series of lectures
by faculty from the Pharmacology Department as well as external experts
who use genomic tools to study and develop cancer therapeutics, followed
by student review and discussion of recent papers in the field that have
made an impact on cancer therapeutics. The course will cover a range of
topics from the application of genomics for target discovery using DNA
microarrays, target identification for cancer therapeutics based on abnormalities
in the cancer cell versus the normal cell and noninvasive imaging of tumors.
Topics will include drug discovery process from rational structure-based
computer modeling to clinical application, resistance mechanisms in the
tumor and pharmacogenomics of the host that determine sensitivity to drugs.
Lectures will also cover gene therapy strategies for attacking tumor cells
based on knowledge gained from functional genomics of tumor cells.
Phar-5575
Signal Transduction
(F)
2 cr.
Ryazanov.
Prerequisite: Permission of instructor.
This course is designed to provide an
introduction to contemporary literature on the biology, pharmacology and
molecular biology of the cell cycle through didactic lectures and student
presentations.
Phar-TBA
Seminar in Pharmacology
(F/S)
1 cr.
Faculty
and student presentations.
Phar-TBA
Research in Pharmacology
(F/S)
(BA,BA)
Supervised
research leading to the Ph.D.
Phar-5601
Genetics in Pharmacology
(F)
2 cr.
Walworth, Lobel. Prerequisite: Permission of instructor.
Genetic strategies are playing an increasingly
important role in understanding drug mechanisms and in the search for
new pharmaceutically active agents. Student taking the course “Genetics
in Pharmacology” will read, evaluate, present, and discuss papers from
recent scientific literature that deals with these topics. Some
familiarity with genetics is advisable.
Phar-5603
Cancer Pharmacology
(S)
2 cr.
Jin,
Liu. Prerequisite: Permission of instructor.
The seminar course is to provide
students with an understanding in the general principles in cancer pharmacology
from the basic science perspective. It will cover areas including mechanism
of actions of the anti-tumor agents, the design and discovery of anti-cancer
drugs, and discovery of basic signaling mechanisms that constitute the
targets of molecules used for cancer therapy. Moreover, novel strategies
for cancer drug discovery will be discussed.
Phar-5606
Hormones & their Receptors
(F)
2 cr.
Chen,
Fondell: Prerequisite: Permission by Instructor.
Steriods and non-steroid hormones control numerous physiological processes in higher organisms, and they also are increasingly
important for modern pharmcacology and drug discovery. This course provides a comprehensive and in-depth coverage of modern theories of hormone action at the
cellular and molecular levels. Students are required to evaluate and present research articles with background introduction on select topics.
Familiarity with Biochemistry, Cell Biology, and Molecular Biology is advisable.
*Admission to the doctoral program is handled
by the consolidated graduate program in molecular biosciences. For further
information, refer to the molecular biosciences heading within this chapter.
Return to the Cellular
and Molecular Pharmacology Graduate Program Home Page
|