Total Credits: 3
RU Course Number: 16:761:600
UMDNJ Course Number: PHYS5720S
Tuesdays, 1:00 – 2:30 pm
Thursdays, 1:00 – 2:30 pm
Prerequisites: Biochemistry 5501 and 5502 or equivalent, Molecular Basis of Physiology or equivalent physiology course.
Fall Semester 2008 and alternatively taught every other year
Room: Waksman 311
Course Coordinator:
Gary J. Grover, Ph.D., Associate Professor
Department of Physiology and Biophysics
(732) 235-4552 or 732 438 5100 ext 265
grovergj@umdnj.edu/garygrover@productsafetylabs.com
Participating Faculty Members: Drs. Ma, Partridge, Zachow, Weiss, Stevenson, Grover, Riley , England , Sarkar, Sesti, Seto-Young(Beth Israel), Fan, lenard, Tsai, Fondell, Ruan
Textbook: Boron and Boulpaep, Medical Physiology, Updated Edition
Overall goal of the course: This is an advanced lecture/discussion format course that covers systems physiology and relates these concepts to disease. The course is divided into organ systems starting with normal physiology that will be needed to set the foundation for understanding the pathophysiology discussed at the end of each section or block. Included are discussions of the cardiovascular, skeletal muscle, pulmonary, renal, gastrointestinal, and endocrine systems in the context of normal function, as well as the effect and consequences of representative pathophysiological conditions within these systems. A total of 26 formal lectures will be given by faculty members, and a total of 1-2 journal articles covering metabolic syndrome will be assigned to participating students for critique and discussion. There will be a mid-term examination and a final examination. The exams will cover material presented in both formal lectures and discussion papers. Each exam will count for 40% of the total grade. The averaged scores from the paper summary critiques and class participation will constitute the remaining 20% of the final grade.
Physiological Basis of Disease, Fall, 2008
Week 1
Sept. 2 nd 1.5 hours: Review of cell function and reaction of cells in distress, Dr. Fan
Sept. 4 th 1.5 hours: CV. Electrical activity, ECG, Dr. Sesti
Week 2
Sept. 9 th 1.5 hours: CV. Cardiac function, cardiac output, venous return, Dr. Weiss
Sept. 11 th 1.5 hours: CV. Microcirculation, Dr. Weiss
Week 3
Sept. 16 th 1.5 hours: CV. Acute myocardial ischemia, heart failure, Dr. Weiss
Sept. 18 th 1.5 hours: Pulmonary mechanics, pulmonary circulation, Dr. England , Dr. Grover
Week 4
Sept. 23 rd 1.5 hours: Oxygen/CO 2 exchange, V/Q imbalance, Dr. Grover
Sept. 25 th 1.5 hours: Pulmonary obstructive disease, restrictive disease, acute respiratory distress syndrome, Dr. David Riley
Week 5
Sept. 30 th 1 hour: Skeletal muscle function, 0.5 hours pathophysiology of muscle, Dr. Ma
Oct.2 nd 1.5 hours: Pathophysiology of muscle: sarcopenia of aging, muscular dystrophy, malignant hyperthermia, Dr. Ma
Week 6
Oct.7 yh 1.5 hours: midterm exam
Oct.9 th 1.5 hours: Renal Physiology, : Body fluid balance; GFR; tubular transport mechanisms, Dr. Zachow
Week 7
Oct.14 th 1.5 hours: Renal Physiology: Renal ion, glucose, and H 2 O handling; the renin-angiotensin system, Dr. Zachow
Oct.16 th 1.5 hours: Renal Physiology: Hormonal regulation of renal Na + and H 2 O handling: aldosterone, AVP, and AII; renal control of blood pressure, Dr. Zachow
Week 8
Oct.21 st 1.5 hours: Renovascular hypertension, diabetic kidney, Dr. Zachow
Oct.23 nd 1.5 hours: Acid-Base Homeostasis, respiratory control, renal control, Dr. Lenard
Week 9
Oct.28 th 1.5 hours: GI, Motility/GI secretion, Dr. Stevenson
Oct.30 th 1.5 hours: GI, Digestion/absorption Dr. Stevenson
Week 10
Nov. 4 th 1.5 hours: 1.5 hours: Gastroesaphageal reflux disease (GERD), irritable bowel disease, hyperacidity, Dr. Stevenson
Nov. 6 th Endocrine, general neuroendocrine: Dr. Dipak Sarkar
Week 11
Nov. 11 th Endocrine pancreas: Dr. Hong Ruan
Nov. 13 th 1.5 hours: Thyroid, adrenals (discuss pathology with this section, hypo, hyper thyroidism; Cushings disease, Addison 's disease), Dr. Fondell
Week 12
Nov. 18 th 1.5 hours: Male reproductive system, Dr. Tsai
Nov. 20 th Female reproductive endocrinology, Dr. Partridge
Week 13
Nov 25 th Female reproductive endocrinology (discuss some pathology with this lecture, polycystic ovary syndrome), Dr. Partridge
Nov 27 th Thanksgiving holiday
Week 14
Dec. 2 nd 1.5 hours: Diabetes, obesity: Dr. Donna Seto-Young
Dec. 4 th Metabolic syndrome paper discussion: Dr. Donna Seto-Young
Week 15
Dec. 9 th 1.5 hours: Calcium regulation (bone disorders might be discussed), Dr. Partridge
Dec. 16 th Final exam