Qifeng Yang, M.D., Ph.D.

Adjunct Associate Professor

Tel: 732-239-9649
Email: qifengy@gmail.com

Education:

• Ph.D.        Wakayama Medical University, Wakayama, Japan
• M.S.         School of Medicine, Shandong University, China
• M.D.         School of Medicine, Shandong University, China

Academic Appointments:

• Adjunct Assistant Professor

Honors/Certificates:

• IAP 2000 Award, Nagoya, Japan
• Wakayama Medical Research Award for Young Researchers (2001) , Japan
• Japanese Government Scholarship (No.014563), from Minister of Education, Culture, Sports, Science and Technology, Government of Japan
• AstraZeneca Scholars Award 2002, 25 th Annual San Antonio Breast Cancer Symposium (SABCS)
• As peer reviewer for international journals: Clinical Cancer Research; International Journal of Cancer; Medical Science Monitor; Histology and Histopathology; Clinical Breast Cancer; Cancer Letters; Cancer Detection and Prevention; Future Oncology; Journal of Clinical Pathology, etc
• Included in information books: MARQUIS Who'sWho in Medicine and Healthcare; MARQUIS Who'sWho in Science and Engineering; MARQUIS Who'sWho in the World; EMPIRE Who'sWho 2004/2005 “Honors Edition”

Research Interests:

• Molecular biology, pathology, genetics and epigenetics of carcinomas especially focusing on breast cancer.  Understanding the molecular basis of breast cancer development and progression.  Identifying novel diagnostic, predictive and prognostic markers towards cancer early detection, chemoprevention and individual treatment.
  

Selected Peer-Reviewed Publications for the Recent 5 Years:

1. Haffty, B. G., Yang, Q., Reiss, M., Kearney, T., Higgins, S. A., Weidhaas, J., Harris, L., Hait, W., and Toppmeyer, D. Locoregional Relapse and Distant Metastasis in Conservatively Managed Triple Negative Early-Stage Breast Cancer. J Clin Oncol, 2006.
2. Haffty, B. G., Kim, J. H., Yang, Q., and Higgins, S. A. Concurrent chemo-radiation in the conservative management of breast cancer. Int J Radiat Oncol Biol Phys, 66: 1306-1312, 2006.
3. Parikh, R., Yang, Q., Haffty, B.G.. Prognostic Significance of Vascular Endothelial Growth Factor protein levels in T1-2 N0 Laryngeal Cancer treated with Primary Radiation Therapy. Cancer (in press)
4. Hu, G., Wang, H. Y., Greenawalt, D. M., Azaro, M. A., Luo, M., Tereshchenko, I. V., Cui, X., Yang, Q., Gao, R., Shen, L., and Li, H. AccuTyping: new algorithms for automated analysis of data from high-throughput genotyping with oligonucleotide microarrays. Nucleic Acids Res, 34: e116, 2006.
5. Yu, Z., Sun, J., Zhen, J., Zhang, Q., and Yang, Q. Thymidylate synthase predicts for clinical outcome in invasive breast cancer. Histol Histopathol, 20: 871-878, 2005.
6. Wang, H. Y., Luo, M., Tereshchenko, I. V., Frikker, D. M., Cui, X., Li, J. Y., Hu, G., Chu, Y., Azaro, M. A., Lin, Y., Shen, L., Yang, Q., Kambouris, M. E., Gao, R., Shih, W., and Li, H. A genotyping system capable of simultaneously analyzing >1000 single nucleotide polymorphisms in a haploid genome. Genome Res, 15: 276-283, 2005.
7. Nakamura, M., Morimoto, S., Yang, Q., Hisamatsu, T., Hanai, N., Nakamura, Y., Mori, I., and Kakudo, K. Osteoclast-like cells express receptor activity modifying protein 2: application of laser capture microdissection. J Mol Endocrinol, 34: 257-261, 2005.
8. Yang, Q. Is bcl-2 useful to select endocrine therapy for breast cancer? Clin Breast Cancer, 5: 370, 2004.
9. Sato, M., Taniguchi, E., Kagiya, T., Nunobiki, O., Yang, Q., Nakamura, M., Nakamura, Y., Mori, I., and Kakudo, K. A modified rapid Papanicolaou stain for imprint smears. Acta Cytol, 48: 461-462, 2004.
10. Yang, Q., Sakurai, T., Yoshimura, G., Suzuma, T., Umemura, T., Nakamura, M., Nakamura, Y., Mori, I., and Kakudo, K. Prognostic value of Bcl-2 in invasive breast cancer receiving chemotherapy and endocrine therapy. Oncol Rep, 10: 121-125, 2003.
11. Tang, W., Nakamura, Y., Zuo, H., Yasuoka, H., Yang, Q., Wang, X., Nakamura, M., Mori, I., Miyauchi, A., and Kakudo, K. Differentiation, proliferation and retinoid receptor status of papillary carcinoma of the thyroid. Pathol Int, 53: 204-213, 2003.
12. Suzuma, T., Sakurai, T., Yoshimura, G., Umemura, T., Shimizu, Y., Yang, Q. F., and Okamura, Y. Anastrozole-induced remission of diaphragmatic paralysis from metastatic breast cancer treated with multiple prior therapies. Breast Cancer, 10: 153-156, 2003.
13. Nakamura, Y., Yasuoka, H., Tsujimoto, M., Yang, Q., Tsukiyama, A., Imabun, S., Nakahara, M., Nakao, K., Nakamura, M., Mori, I., and Kakudo, K. Clinicopathological significance of vascular endothelial growth factor-C in breast carcinoma with long-term follow-up. Mod Pathol, 16: 309-314, 2003.
14. Nakamura, Y., Yasuoka, H., Tsujimoto, M., Yang, Q., Imabun, S., Nakahara, M., Nakao, K., Nakamura, M., Mori, I., and Kakudo, K. Prognostic significance of vascular endothelial growth factor D in breast carcinoma with long-term follow-up. Clin Cancer Res, 9: 716-721, 2003.
15. Yang, Q., Yoshimura, G., Sakurai, T., and Kakudo, K. The Fragile Histidine Triad gene and breast cancer. Med Sci Monit, 8: RA140-144, 2002.
16. Yang, Q., Yoshimura, G., Nakamura, M., Nakamura, Y., Suzuma, T., Umemura, T., Mori, I., Sakurai, T., and Kakudo, K. BRCA1 in non-inherited breast carcinomas. Oncol Rep, 9: 1329-1333, 2002.
17. Yang, Q., Yoshimura, G., Nakamura, M., Nakamura, Y., Suzuma, T., Umemura, T., Mori, I., Sakurai, T., and Kakudo, K. Correlation between BRCA1 expression and apoptosis-related biological parameters in sporadic breast carcinomas. Anticancer Res, 22: 3615-3619, 2002.
18. Yang, Q., Yoshimura, G., Mori, I., Sakurai, T., and Kakudo, K. Chromosome 3p and breast cancer. J Hum Genet, 47: 453-459, 2002.
19. Yang, Q., Yoshimura, G., Mori, I., Sakurai, T., and Kakudo, K. Thymidine phosphorylase and breast carcinoma. Anticancer Res, 22: 2355-2360, 2002.
20. Yang, Q., Shan, L., Yoshimura, G., Nakamura, M., Nakamura, Y., Suzuma, T., Umemura, T., Mori, I., Sakurai, T., and Kakudo, K. 5-aza-2'-deoxycytidine induces retinoic acid receptor beta 2 demethylation, cell cycle arrest and growth inhibition in breast carcinoma cells. Anticancer Res, 22: 2753-2756, 2002.
21. Yang, Q., Sakurai, T., and Kakudo, K. Retinoid, retinoic acid receptor beta and breast cancer. Breast Cancer Res Treat, 76: 167-173, 2002.
22. Yang, Q., Nakamura, Y., Nakamura, M., Yoshimura, G., Suzuma, T., Umemura, T., Mori, I., Sakurai, T., and Kakudo, K. Loss of Msh2 is not associated with FHIT deletion in breast carcinomas. Anticancer Res, 22: 2591-2595, 2002.
23. Yang, Q., Nakamura, M., Nakamura, Y., Yoshimura, G., Suzuma, T., Umemura, T., Tamaki, T., Mori, I., Sakurai, T., and Kakudo, K. Correlation of prostate-specific antigen promoter polymorphisms with clinicopathological characteristics in breast cancer. Anticancer Res, 22: 1825-1828, 2002.
24. Yang, Q., Nakamura, M., Nakamura, Y., Yoshimura, G., Suzuma, T., Umemura, T., Shimizu, Y., Mori, I., Sakurai, T., and Kakudo, K. Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer. Clin Cancer Res, 8: 2890-2893, 2002.
25. Yang, Q., Barbareschi, M., Mori, I., Mauri, F., Muscara, M., Nakamura, M., Nakamura, Y., Yoshimura, G., Sakurai, T., Caffo, O., Galligioni, E., Dalla Palma, P., and Kakudo, K. Prognostic value of thymidine phosphorylase expression in breast carcinoma. Int J Cancer, 97: 512-517, 2002.
26. Utsunomiya, H., Ueshima, H., Kawashiro, M., Yang, Q., Nakamura, M., Nakamura, Y., Sakurai, T., Mori, I., and Kakudo, K. Thymidine phosphorylase is regulated by tamoxifen in T47D breast cancer cell line. Breast Cancer, 9: 107-110, 2002.
27. Tang, W., Taniguchi, E., Wang, X., Mori, I., Kagiya, T., Yang, Q., Nakamura, Y., Nakamura, M., Yoshimura, G., Sakurai, T., and Kakudo, K. Loss of cell cohesion in breast cytology as a characteristic of neuroendocrine carcinoma. Acta Cytol, 46: 835-840, 2002.
28. Suzuma, T., Sakurai, T., Yoshimura, G., Umemura, T., Tamaki, T., Yang, Q. F., Oura, S., and Naito, Y. MR-axillography oriented surgical sampling for assessment of nodal status in the selection of patients with breast cancer for axillary lymph nodes dissection. Breast Cancer, 9: 69-74, 2002.
29. Sato, M., Nakamura, Y., Sogawa, T., Yang, Q., Taniguchi, T., Taniguchi, E., Kagiya, T., Nakamura, M., Mori, I., and Kakudo, K. Immunolocalization of glucose transporter 1 and 3 in the placenta: application to cytodiagnosis of Papanicolaou smear. Diagn Cytopathol, 26: 373-379, 2002.
30. Nakamura, M., Yang, Q., Ozaki, T., Nakamura, Y., Yamasaki, H., Mori, I., and Kakudo, K. Induction of uPA but not NF-IL3A by calcitonin is dependent on Erk1/2 phosphorylation in porcine renal cell line LLC-PK1. Biochem Biophys Res Commun, 290: 1483-1488, 2002.
31. Mori, I., Yang, Q., and Kakudo, K. Predictive and prognostic markers for invasive breast cancer. Pathol Int, 52: 186-194, 2002.
32. Yang, Q., Yoshimura, G., Suzuma, T., Tamaki, T., Umemura, T., Nakamura, M., Nakamura, Y., Wang, X., Mori, I., Sakurai, T., and Kakudo, K. Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma. Clin Cancer Res, 7: 3869-3873, 2001.
33. Yang, Q., Yoshimura, G., Nakamura, M., Nakamura, Y., Shan, L., Suzuma, T., Tamaki, T., Umemura, T., Mori, I., and Kakudo, K. Allelic loss of chromosome 3p24 correlates with tumor progression rather than with retinoic acid receptor beta2 expression in breast carcinoma. Breast Cancer Res Treat, 70: 39-45, 2001.
34. Yang, Q., Shan, L., Segawa, N., Nakamura, M., Nakamura, Y., Mori, I., Sakurai, T., and Kakudo, K. Novel polymorphisms in prostate specific antigen gene and its association with prostate cancer. Anticancer Res, 21: 197-200, 2001.
35. Yang, Q., Sakurai, T., Yoshimura, G., Mori, I., Nakamura, M., Nakamura, Y., Suzuma, T., Tamaki, T., Umemura, T., and Kakudo, K. Hypermethylation does not account for the frequent loss of the retinoic acid receptor beta2 in breast carcinoma. Anticancer Res, 21: 1829-1833, 2001.
36. Yang, Q., Sakurai, T., Mori, I., Yoshimura, G., Nakamura, M., Nakamura, Y., Suzuma, T., Tamaki, T., Umemura, T., and Kakudo, K. Prognostic significance of BRCA1 expression in Japanese sporadic breast carcinomas. Cancer, 92: 54-60, 2001.
37. Yang, Q., Mori, I., Shan, L., Nakamura, M., Nakamura, Y., Utsunomiya, H., Yoshimura, G., Suzuma, T., Tamaki, T., Umemura, T., Sakurai, T., and Kakudo, K. Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer. Am J Pathol, 158: 299-303, 2001.
38. Yang, Q., Mori, I., Sakurai, T., Yoshimura, G., Suzuma, T., Nakamura, Y., Nakamura, M., Taniguchi, E., Tamaki, T., Umemura, T., and Kakudo, K. Correlation between nuclear grade and biological prognostic variables in invasive breast cancer. Breast Cancer, 8: 105-110, 2001.
39. Wang, X., Mori, I., Tang, W., Yang, Q., Nakamura, M., Nakamura, Y., Sato, M., Sakurai, T., and Kennichi, K. Metaplastic carcinoma of the breast: p53 analysis identified the same point mutation in the three histologic components. Mod Pathol, 14: 1183-1186, 2001.
40. Taniguchi E, Y. Q., Tang W, Nakamura Y, Shan L, Nakamura M, Mori I, Sakurai T, Kakudo K. Cytological grading of invasive breast carcinoma. Acta Cytologica, 45 , 2001.
41. Shan, L., Yang, Q., Nakamura, Y., Nakamura, M., Miyauchi, A., Tsujimoto, M., Nakatani, Y., Wakasa, K., Mori, I., and Kakudo, K. Frequent loss of heterozygosity at 1p36.3 and p73 abnormality in parathyroid adenomas. Mod Pathol, 14: 273-278, 2001.
42. Nakamura, M., Yang, Q., Gouda, T., Takehara, A., Ohta, H., Miyajima, M., and Kakudo, K. Loss of calcitonin binding in rat is not related to calcitonin receptor gene abnormality. Biochem Biophys Res Commun, 284: 1184-1188, 2001.