Selected Publications till 2000

Selected Publications

Published

W. Xie, D.L. Rimm, Y. Lin, W.J. Shih, and M. Reiss (2003), Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis. The Cancer Journal, vol. 9, no. 4 July/August, p302-312.

D.L. Toppmeyer, M. Gounder, J. Much, R. Musanti, V. Vyas, M. Medina, T. Orlando, M. Pennick, Y. Lin, W.J. Shih, S. Goodin, E.H. Rubin.(2003) A phase I and pharmacologic study of the combination of marimastat and paclitaxel in patients with advanced malignancies. Med. Sci. Monit, 9(8): p199-104

E.J. Licitra, V. Vyas, K. Nelson, R. Musanti, S. Beers, C. Thomas, E. Poplin, S. Smith, Y. Lin, L.J. Schaaf, J. Aisner, M. Gounder, R. Rajendra, A. Saleem, D. Roppmeyer, and E.H. Rubin (2003), Phase I evaluation of sequential Topoisomerase targeting with Irinotecan/Cisplatin followed by Etoposide in patients with advanced malignancy, Clinical Cancer Research, vol. 9, 1673-1679.

W.J. Shih, P. Ouyang, H. Quan, Y. Lin, B. Michiels, and L. Bijnens (2003), Controlling type-I error rate for fast track drug development programs. Statistics in Medicine, vol.22, 665-675.

X. Zheng, R.Ravatn, Y. Lin, W.J. Shih, A. Rabson, R. Strair, E. Huberman, A.H. Conney, and K.V. Chin (2002), Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis, Nucleic Acids Research, Vol. 30, no. 20, 4489-4499.

Y.P. Lu, Y.R. Lou, X.H. Li, J.G. Xie, Y. Lin, W.J. Shih, and A.H. Conney (2002), Stimulatory Effects of topical application of caffeine on UVB-induced apoptosis in mouse skin. Oncology Research/Anti-Cancer Drug Design, Vol. 13, 61-70.

R. Ravatn, B. Feng, Y. Lin, W.J. Shih, K.V. Chin, and D. B. Seifer (2002), DNA Microarray Analysis of the Expression Profiles of Granulosa Cells as a Function of Ovarian Reserve, Fertility and Sterility, June 2002, vol. 77, no. 6, 1214-1218.

R.S. DiPaola, E.S. Chenven, W.J. Shih, Y. Lin, P. Amenta, S. Goodin, A. Shumate, M.M. Rafi, T. Capanna, M. Cardiella, K.B. Cummings and M. B. Tood (2001). Mitoxantrone in Patients with Prostate Specific Antigen Progression after Local Therapy for Prostate Cancer, Cancer, 92, 2065-71, 2001.

X. Zheng, R. L. Chang, X.X. Cui, K.A. Kelly, W.J. Shih, Y. Lin, R.Strair, J. Sun, Z.T. Han, A. Rabson and A.H. Conney (2001), Synergistic effects of clinically achievable concentrations of 12-O-tetradecanoylphorbol-13-acetate in combination with all-trans retinoic acid, 1a, 25-dihydroxyvitamin D3 and sodium butyrate on differentiation in HL-60 cells, Oncology Research, Vol.12, 419-427..

Y. Lin and W.J. Shih (2001), An adaptive Two-Statge Design for Phase II Clinical Trials, 2001 ENAR Spring Meeting of The International Biometrics Society in Charlotte of North Carolina (March 25-28 of 2001) (Also submitted for publication).

Y. Lin and W.J. Shih (2001), Statistical properties of the traditional algorithm-based designs for phase-I cancer clinical trials, Biostatistics, vol 2, 203-215

Y.P. Lu, Y.R. Lou, Y. Lin, W.J. Shih, M.T. Huang, C.S. Yang and A.H. Conney (2001), Inhibitory effects of orally administered green tea, black tea and caffeine on skin carcinogenesis in mice previously treated with UVB (high risk mice): relationship to decreased tissue fat, Cancer Research, 61, 5002-5009.

J. Yang, J.M. Yang, M. Iannone, W.J. Shih, Y. Lin, and W.N. Hait (2001), Disruption of the EF-2 Kinase/Hsp90 Protein Complex: A Possible Mechanism to Inhibit Glioblastoma by Geldanamycin, Cancer Research, 61, 4010-4016.

R.M. Zamek, D. L. Toppmeyer, V. Vyas, A. Saleem, J. Much, E. Poplin, M. Medina, Y. Lin, L. J. Schaaf, and E. H. Rubin (2000), Phase I and Pharmacologic Evaluation of Sequential Topoisomerase (Top) Targeting with Irionotecan(I) and Etoposide (E) in Combination with Cisplatin. Proc Am Soc Clin Oncol: 2000; 19:A773.

Y. Ye and Y. Lin (2000), Using SAS functions in data steps, PharmaSUG 2000 in Seattle of Washington in May 7-10 of 2000.

W.J. Shih, L. Wei, Y. Lin, F. Liu, and H. Quan (2000), Less May Be More --"Pattern But Not Mix" And "Partial Imputation" Approaches For Analyzing Clinical Data With Dropouts, 2000 ENAR Spring Meeting of The International Biometrics Society in Chicago of Illinois in March 19-22 of 2000.

W.J. Shih, J.J. Lee and Y. Lin (1999), A hybrid of modified CRM and EWOC approaches for Phase-I cancer trails, 1999 ENAR Spring Meeting of The International Biometrics Society in Atlanta of Georgia.

Y. Lin and B.G. Lindsay (1997), Projections on cones, Chi-bar squared distributions, and Weyl's formula, Statistics and Probability Letters, vol. 32, 367-376.

Y. Lin (1997), The likelihood ratio test of mixture hypotheses and the tube volume problem, Ph.D. Thesis, Statistics Department, The Pennsylvania State University.

Y. Lin and B.G. Lindsay (1996), The likelihood ratio test of mixture hypotheses: distributional approximation using Hotelling's tubes, 1996 Joint Statistical Meetings in Chicago.

Y. Lin (1994), On the systems of Boussinesque equations, Master paper, Mathematics Department, The Pennsylvania State University.

Y. Lin (1987), On Point Derivations of Higher Order on R(K), Journal of Xiamen University (Natural Science), vol.26, no.2 154-160.

Y. Lin (1986), alpha-fine Topology and Julia Points of a Homomorphic Function, Journal of Xiamen University (Natural Science), vol.25, no.4 400-407.

Submitted or In Preparation

Y. Lin and W.J. Shih, An adaptive Two-Statge Design for Phase II Clinical Trials (submitted for publication).

S.E. Lu, Y. Lin and W.J. Shih, Analyzing excessive no changes in clinical trials with clustered data (submitted for publication)

W.J. Shih, P.A. Strickland, and Y. Lin, Analyses of Pilot and Early Phase Studies with Small Sample Sizes (submitted for publication)

J.G. Liao, Y. Lin and W.J. Shih, A flexible and robust mixture model for multiple testing in DNA microarray (submitted for publication)

P. M. Lehrer, E. Vaschillo, B. Vaschillo, S.E. Lu, R. Edelberg, W.J. Shih, Y. Lin. Modification of baroreflex gain and pulmonary function among healthy people using rate biofeedback training (Submitted for publication)

M.K.Gounder, S.L Sun, H. Sands, Y. Lin, W.J. Shih, Z. Gu, M. Roychowdhury, R. Rajendra, E. H. Rubin, Development of an enzyme based- high performance liquid chromatography method for quantitation of 9-nitrocamptothecin in human plasma (submitted for publication)

Y. F. Wong, E. Selvanayagam, J. Porter, N. Wei, R. Vittal, R Hu, Y. Lin, J. Liao, J. W. Shih, T. H. Cheung, K. W. K. Lo, S. F. Yim, S. Kai Yip, D. T. Ngong, N. Siu, L. K. Y. Chan, C. S. Chan, T. Kong, E. Kutlina, R. D. McKinnon, D. T. Denhardt, K. V. Chin, and T. K. Hung Chung. Expression Genomics of Cervical Cancer: Molecular Classification and Prediction of Radiotherapeutic Response by DNA Microarray (submitted for publication)

L. Michna, Y. P. Lu, W.J. Shih, Y. Lin, A. H. Conney and G. Wagner, Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice (in preparation)

X. Zheng, R. L. Chang, X.X. Cui, G.E. Avila, S. Lee, Y. P. Lu, Y. R. Lou, W.J. Shih, Y. Lin, K. Reuhl, H. Newmark, A. Rabson and A. H. Conney, Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) alone or in combination with all-trans retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice (in preparation)

Last Updated: 9/30/03

	W. Xie, D.L. Rimm, Y. Lin, W.J. Shih, and M. Reiss (2003), Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis. The Cancer Journal, vol. 9, no. 4 July/August, p302-312.
	D.L. Toppmeyer, M. Gounder, J. Much, R. Musanti, V. Vyas, M. Medina, T. Orlando, M. Pennick, Y. Lin, W.J. Shih, S. Goodin, E.H. Rubin.(2003) A phase I and pharmacologic study of the combination of marimastat and paclitaxel in patients with advanced malignancies. Med. Sci. Monit, 9(8): p199-104
	E.J. Licitra, V. Vyas, K. Nelson, R. Musanti, S. Beers, C. Thomas, E. Poplin, S. Smith, Y. Lin, L.J. Schaaf, J. Aisner, M. Gounder, R. Rajendra, A. Saleem, D. Roppmeyer, and E.H. Rubin (2003), Phase I evaluation of sequential Topoisomerase targeting with Irinotecan/Cisplatin followed by Etoposide in patients with advanced malignancy, Clinical Cancer Research, vol. 9, 1673-1679.
	W.J. Shih, P. Ouyang, H. Quan, Y. Lin, B. Michiels, and L. Bijnens (2003), Controlling type-I error rate for fast track drug development programs. Statistics in Medicine, vol.22, 665-675.
	X. Zheng, R.Ravatn, Y. Lin, W.J. Shih, A. Rabson, R. Strair, E. Huberman, A.H. Conney, and K.V. Chin (2002), Gene expression of TPA induced differentiation in HL-60 cells by DNA microarray analysis, Nucleic Acids Research, Vol. 30, no. 20, 4489-4499.
	Y.P. Lu, Y.R. Lou, X.H. Li, J.G. Xie, Y. Lin, W.J. Shih, and A.H. Conney (2002), Stimulatory Effects of topical application of caffeine on UVB-induced apoptosis in mouse skin. Oncology Research/Anti-Cancer Drug Design, Vol. 13, 61-70.
	R. Ravatn, B. Feng, Y. Lin, W.J. Shih, K.V. Chin, and D. B. Seifer (2002), DNA Microarray Analysis of the Expression Profiles of Granulosa Cells as a Function of Ovarian Reserve, Fertility and Sterility, June 2002, vol. 77, no. 6, 1214-1218.
	R.S. DiPaola, E.S. Chenven, W.J. Shih, Y. Lin, P. Amenta, S. Goodin, A. Shumate, M.M. Rafi, T. Capanna, M. Cardiella, K.B. Cummings and M. B. Tood (2001). Mitoxantrone in Patients with Prostate Specific Antigen Progression after Local Therapy for Prostate Cancer, Cancer, 92, 2065-71, 2001.
	X. Zheng, R. L. Chang, X.X. Cui, K.A. Kelly, W.J. Shih, Y. Lin, R.Strair, J. Sun, Z.T. Han, A. Rabson and A.H. Conney (2001), Synergistic effects of clinically achievable concentrations of 12-O-tetradecanoylphorbol-13-acetate in combination with all-trans retinoic acid, 1a, 25-dihydroxyvitamin D3 and sodium butyrate on differentiation in HL-60 cells, Oncology Research, Vol.12, 419-427..
	Y. Lin and W.J. Shih (2001), An adaptive Two-Statge Design for Phase II Clinical Trials, 2001 ENAR Spring Meeting of The International Biometrics Society in Charlotte of North Carolina (March 25-28 of 2001) (Also submitted for publication).
	Y. Lin and W.J. Shih (2001), Statistical properties of the traditional algorithm-based designs for phase-I cancer clinical trials, Biostatistics, vol 2, 203-215
	Y.P. Lu, Y.R. Lou, Y. Lin, W.J. Shih, M.T. Huang, C.S. Yang and A.H. Conney (2001), Inhibitory effects of orally administered green tea, black tea and caffeine on skin carcinogenesis in mice previously treated with UVB (high risk mice): relationship to decreased tissue fat, Cancer Research, 61, 5002-5009.
	J. Yang, J.M. Yang, M. Iannone, W.J. Shih, Y. Lin, and W.N. Hait (2001), Disruption of the EF-2 Kinase/Hsp90 Protein Complex: A Possible Mechanism to Inhibit Glioblastoma by Geldanamycin, Cancer Research, 61, 4010-4016.
	R.M. Zamek, D. L. Toppmeyer, V. Vyas, A. Saleem, J. Much, E. Poplin, M. Medina, Y. Lin, L. J. Schaaf, and E. H. Rubin (2000), Phase I and Pharmacologic Evaluation of Sequential Topoisomerase (Top) Targeting with Irionotecan(I) and Etoposide (E) in Combination with Cisplatin. Proc Am Soc Clin Oncol: 2000; 19:A773.
	Y. Ye and Y. Lin (2000), Using SAS functions in data steps, PharmaSUG 2000 in Seattle of Washington in May 7-10 of 2000.
	W.J. Shih, L. Wei, Y. Lin, F. Liu, and H. Quan (2000), Less May Be More --"Pattern But Not Mix" And "Partial Imputation" Approaches For Analyzing Clinical Data With Dropouts, 2000 ENAR Spring Meeting of The International Biometrics Society in Chicago of Illinois in March 19-22 of 2000.
	W.J. Shih, J.J. Lee and Y. Lin (1999), A hybrid of modified CRM and EWOC approaches for Phase-I cancer trails, 1999 ENAR Spring Meeting of The International Biometrics Society in Atlanta of Georgia.
	Y. Lin and B.G. Lindsay (1997), Projections on cones, Chi-bar squared distributions, and Weyl's formula, Statistics and Probability Letters, vol. 32, 367-376.
	Y. Lin (1997), The likelihood ratio test of mixture hypotheses and the tube volume problem, Ph.D. Thesis, Statistics Department, The Pennsylvania State University.
	Y. Lin and B.G. Lindsay (1996), The likelihood ratio test of mixture hypotheses: distributional approximation using Hotelling's tubes, 1996 Joint Statistical Meetings in Chicago.
	Y. Lin (1994), On the systems of Boussinesque equations, Master paper, Mathematics Department, The Pennsylvania State University.
	Y. Lin (1987), On Point Derivations of Higher Order on R(K), Journal of Xiamen University (Natural Science), vol.26, no.2 154-160.
	Y. Lin (1986), alpha-fine Topology and Julia Points of a Homomorphic Function, Journal of Xiamen University (Natural Science), vol.25, no.4 400-407.

	Y. Lin and W.J. Shih, An adaptive Two-Statge Design for Phase II Clinical Trials (submitted for publication).
	S.E. Lu, Y. Lin and W.J. Shih, Analyzing excessive no changes in clinical trials with clustered data (submitted for publication)
	W.J. Shih, P.A. Strickland, and Y. Lin, Analyses of Pilot and Early Phase Studies with Small Sample Sizes (submitted for publication)
	J.G. Liao, Y. Lin and W.J. Shih, A flexible and robust mixture model for multiple testing in DNA microarray (submitted for publication)
	P. M. Lehrer, E. Vaschillo, B. Vaschillo, S.E. Lu, R. Edelberg, W.J. Shih, Y. Lin. Modification of baroreflex gain and pulmonary function among healthy people using rate biofeedback training (Submitted for publication)
	M.K.Gounder, S.L Sun, H. Sands, Y. Lin, W.J. Shih, Z. Gu, M. Roychowdhury, R. Rajendra, E. H. Rubin, Development of an enzyme based- high performance liquid chromatography method for quantitation of 9-nitrocamptothecin in human plasma (submitted for publication)
	Y. F. Wong, E. Selvanayagam, J. Porter, N. Wei, R. Vittal, R Hu, Y. Lin, J. Liao, J. W. Shih, T. H. Cheung, K. W. K. Lo, S. F. Yim, S. Kai Yip, D. T. Ngong, N. Siu, L. K. Y. Chan, C. S. Chan, T. Kong, E. Kutlina, R. D. McKinnon, D. T. Denhardt, K. V. Chin, and T. K. Hung Chung. Expression Genomics of Cervical Cancer: Molecular Classification and Prediction of Radiotherapeutic Response by DNA Microarray (submitted for publication)
	L. Michna, Y. P. Lu, W.J. Shih, Y. Lin, A. H. Conney and G. Wagner, Inhibitory effects of voluntary running wheel exercise on UVB-induced skin carcinogenesis in SKH-1 mice (in preparation)
	X. Zheng, R. L. Chang, X.X. Cui, G.E. Avila, S. Lee, Y. P. Lu, Y. R. Lou, W.J. Shih, Y. Lin, K. Reuhl, H. Newmark, A. Rabson and A. H. Conney, Inhibitory effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) alone or in combination with all-trans retinoic acid on the growth of LNCaP prostate tumors in immunodeficient mice (in preparation)